The main antagonist could be one of the powerful and malevolent entities from 'The Suffering'. For example, the big bad demon or the tortured soul that has been corrupted by the darkness of that world and now wants to spread it to Danny's world.
One idea could be to explore how Danny's ghost powers interact with the dark and tortured world of 'The Suffering'. Maybe he gets trapped in that nightmarish realm and has to use his unique abilities to survive and find a way out. Another idea is to have some of the tortured souls from 'The Suffering' cross over into Danny's world and how he deals with them while keeping his identity as a half - ghost a secret.
His friends like Sam and Tucker are likely to be main characters too. They usually support Danny in his adventures and add a human element to the story. Sam with her gothic style and strong will, and Tucker with his tech - savvy skills are important parts of Danny's world.
One possible interesting plotline could be Danny facing a new and more powerful ghost that has a personal vendetta against him. This would test his limits and force him to discover new powers or ways to fight.
I like the idea of a Danny Phantom and Ben 10 crossover. Ben has the Omnitrix which gives him access to different alien forms, and Danny has his ghost powers. They could either be rivals at first, each thinking their powers are better, or they could quickly team up to face a threat that requires both their unique abilities. It would be a fun clash of two very different power - based universes.
There's also 'Suffering in the Shadows'. This fanfiction focuses on Danny's isolation and the way he suffers in silence. He can't fully confide in his friends or family about the true extent of his pain as he battles the supernatural, and the story does an excellent job of portraying his emotional and physical distress.
One idea could be that Danny, as a half - ghost, has to prove himself to the Ghost King. Maybe there's a tournament in the Ghost Zone where Danny enters to show his worth. This could lead to some epic battles and alliances with other ghosts.
One idea could be that Danny, with his ghost powers, ends up in the RWBY universe. He could team up with Team RWBY to fight off Grimm that are being influenced by some sort of ghostly energy. His intangibility and flight would be really useful in battles.
In a crossover, characters from the other franchise might betray Danny. For example, if it's a crossover with a show about vampires, a vampire character who seems friendly at first could betray Danny for his ghost powers. They might want to use his powers for their own dark purposes. Another likely candidate could be a character who is jealous of Danny's abilities. Maybe in a crossover with a superhero world, a sidekick who feels overshadowed by Danny's powers and popularity might be the one to betray him.
I think Danny Phantom crossover fanfictions can be really exciting. They bring together different universes and characters, creating unique and unexpected storylines. For example, a crossover with a superhero universe could lead to Danny teaming up with other heroes to fight a common enemy. It's a great way to explore new character dynamics and expand the Danny Phantom world.