Perhaps the author has a different interpretation of Hermione's character. In the original series, she has great friends, but in this fanfic, the author might think that there were some underlying aspects of her personality that could lead to her being ostracized. It could be related to her intelligence or her sometimes bossy nature, which the author may have exaggerated to make her seem friendless.
One reason could be to create a more complex and angsty story. By making Hermione seem friendless, it can show her in a vulnerable state that we don't often see in the original series. It might also be a way to explore different character arcs for her, like how she copes with isolation and how she eventually finds new relationships or reconciles with old friends.
She could start by joining new study groups or clubs at Hogwarts. Since she's so intelligent, she might find others with similar interests in advanced magic studies or ancient runes.
Harry would be extremely worried and determined to find a cure. He'd probably search every corner of the library and consult all his wizarding contacts. Ron, on the other hand, would be initially in shock but then would try to cheer her up with his clumsy humor.
Hermione's friends from the Ministry of Magic or other magical organizations would also react. Those who respect Hermione for her intelligence and contributions would be supportive. They might offer her more flexible work arrangements so she can take care of the baby. However, there might be some who are envious or judgmental. But overall, Hermione's true friends would surround her and the baby with love and protection.
Harry would probably be very concerned and protective. He's been through a lot himself, and he'd want to be there for Hermione. He might try to comfort her by just sitting with her quietly, sharing his own experiences of tough times to let her know she's not alone.
Harry might be a bit surprised at first. But then he'd understand that it's just another way Hermione is expressing herself. He'd probably be more interested in the meaning behind the tattoos.
In fanfiction, Hermione's Muggle friends are sometimes depicted as being very accepting of her magical life. They don't question it too much and are just happy to be part of her world in a way.
One possible fanfiction could be about Hermione and Ginny teaming up to solve a mystery at Hogwarts. Maybe they notice some strange behavior among the younger students and decide to investigate. Along the way, they rely on their different strengths - Hermione's vast knowledge and Ginny's Quidditch - inspired courage and quick thinking. Their friendship deepens as they face challenges together.
One great fanfiction about Hermione and Theo as best friends is 'The Unlikely Bond'. In this story, it starts with them being forced to work on a project together in Hogwarts. Theo's initially reserved nature and Hermione's studious attitude create an interesting dynamic. As they spend more time together, they discover shared interests beyond academics, like a love for magical creatures. Their friendship grows as they support each other through various challenges, such as Theo dealing with his family's expectations and Hermione facing the pressure of being the top student.