One possible plot twist could be that Naruto struggles to control Itachi's power at first. Since Itachi's power is very different from his own chakra nature. For example, Itachi's genjutsu abilities might be too much for Naruto to handle initially, leading to him accidentally using it on his friends, causing mistrust among them. Another plot twist could be that the Akatsuki targets Naruto more aggressively, believing he has become a greater threat with Itachi's power. They might send their most powerful members after him, like Pain or Obito. Also, Naruto might discover some hidden secrets about Itachi's power that even Itachi was unaware of, which could change the course of the shinobi world's power balance.
His relationship with Sasuke would become extremely complex. Sasuke might see Naruto as a reminder of Itachi, which could stir up a mix of emotions like anger, envy, and also a strange sense of kinship. Naruto, on the other hand, might try to use Itachi's power to understand Sasuke better, but this could be misinterpreted by Sasuke as Naruto trying to take on the role of Itachi in his life. With his friends like Sakura and Kakashi, they might be initially wary of Naruto's new power. Sakura might worry that Naruto is losing himself to Itachi's power, while Kakashi would be more cautious and observant, trying to guide Naruto to use the power in a positive way.
One possible plot could be Naruto struggling to come to terms with having the same disease as Itachi. He might have to deal with the physical limitations and pain, while also trying to keep it a secret from his friends. This could lead to some internal conflict as he doesn't want to worry them, but also needs support.
Naruto's normally upbeat and energetic personality might become more subdued. He'd have to face the reality of his own mortality, which could make him more cautious and less impulsive.
It could be the main character Naruto in some fanfics. Since he already has a connection with the Nine - Tailed Fox, a fanfic writer might expand on that and give him an even more powerful 'Power of the Beast' that combines the Nine - Tailed Fox's power with other beast - like elements.
Well, Naruto might show his prodigious side in a more extroverted way compared to Itachi. Itachi was a prodigy in his calm and calculated skills from a young age. Naruto could be shown as a prodigy in quickly mastering new jutsus or having an uncanny ability to lead and inspire others in the fanfic, much like Itachi was a natural leader in his own way among the Uchiha.
Yes, there are likely fanfics out there with this premise. Fanfiction writers often explore unique relationships that weren't fully developed in the original Naruto series. In such a fanfic, it could lead to some really interesting storylines, like Naruto changing Itachi's fate or them working together to solve the problems in the ninja world in a different way than in the original story.
Yes, in some fanfics, Naruto can be depicted as Itachi's best friend. Writers often like to create unique relationships between characters that deviate from the original storyline for creative purposes.
There's also 'The Unseen Bond' which is a wonderful 'Naruto Itachi Fanfic'. This one focuses on the hidden bond between Naruto and Itachi. It shows how, despite their different loyalties and situations, they share a connection that could be the key to bringing peace to the ninja world. The plot twists in this fanfic are really engaging.
One possible fanfic could focus on a unique friendship between Naruto and a female Itachi. Maybe they meet in an alternate universe where Itachi was born female. They could start by being wary of each other due to their different backgrounds. Naruto, with his sunny personality, might gradually break through Itachi's reserved exterior, leading to a strong bond of trust and mutual understanding.