He might miss out on some crucial training. Jiraiya has a lot of knowledge and skills to pass on, and by running away, Naruto could fall behind in his development as a ninja.
One possible reason could be that Naruto might be afraid of the intense training Jiraiya has in store for him. Jiraiya is known for his strict and grueling training methods, and Naruto, being young and sometimes impatient, might just want to escape that for a while.
Perhaps Naruto feels that Kushina is being overprotective. He wants to prove his independence and go on his own adventures without her constant supervision, so he decides to run away.
Maybe he feels misunderstood by his family. In many Naruto stories, his family situation can be complex. If he's 'godlike', he might have powers that his family doesn't understand or fears, leading him to run away to avoid conflict or being treated differently.
Maybe he's running away from the pressure in the village. There are always high expectations on him, and he might feel suffocated and need some time alone to figure things out.
One possible reason could be fear. Minato is a very powerful shinobi, and Naruto might be scared of him for some reason. Maybe he has heard stories about Minato that made him afraid.
He could become stronger on his own. Away from his family, he'll have to rely solely on himself. This self - reliance might push him to train harder and unlock even more of his 'godlike' powers. For instance, he might find new mentors or training methods that his family would not have allowed.
Another reason could be for the sake of protecting the village. Maybe he discovers some sort of threat that he believes he can only face by leaving Konoha. He doesn't want the village to be in danger because of him, so he runs away to draw the danger away from Konoha.
One possible plot could be that Naruto feels constantly overshadowed by his family's expectations. Maybe his family is full of powerful shinobi and they expect him to be just as great immediately. He runs away to find his own path and prove himself on his own terms. Along the way, he meets new friends who are also outcasts and together they form a sort of 'family' that accepts him for who he is.
One possible reason could be that he feels misunderstood. In the village, he has always faced discrimination because of the Nine - Tails inside him. People often look at him with fear and suspicion. So, he might run away to find a place where he can be accepted for who he is.