In some Avengers fanfictions, Aunt May might die from an attack by a supervillain. For example, if the villains target Spider - Man's loved ones to get to him, Aunt May could be in the crossfire. Maybe a group like the Sinister Six raids Peter Parker's home, and in the chaos, Aunt May is fatally injured.
Aunt May's death in the original comics was often due to various storylines and circumstances, but the specific cause could vary depending on the particular comic run.
The story of Devil May Cry 5 is quite substantial. It takes a decent amount of time to complete, depending on your playstyle and how much you explore the various levels and side quests.