The main differences lie in the way the stories are told and the art style. Mesugaki manga often features more unconventional plots and a distinct visual aesthetic that sets it apart from common manga genres. Also, the target audience might be different, influencing the tone and content.
These comics typically present unconventional gender scenarios and may delve into complex emotional and physical aspects of sexual experiences related to the gender changes. They can be both provocative and thought-provoking.
Sex comics can be for entertainment or have various artistic expressions related to sex. Sex ed is meant to inform and educate. Hentai typically involves highly sexualized and sometimes unconventional scenarios that are not suitable for general audiences.