Sure is. Karen Page has made appearances in various comic series and plays significant roles in some of them. Her character development and interactions contribute to the depth of the comic universe.
Karen Page's fate in the comics is that she dies. However, the way it happens and the impact it has on the story differ based on the specific comic version you're looking at.
Given only 'dateline karen read story', Karen's identity remains a mystery. She might be a staff member at Dateline who was reading a story for work purposes. Or she could be a person who was interviewed by Dateline and was reading a story during the interview, or she could be an ordinary person whose story - reading experience is being highlighted in relation to Dateline.
It's hard to say for sure. 'Karen' could be a blend of real incidents and creative imagination. Sometimes, such stories take real-life inspirations but are embellished for entertainment value.
I don't think there was a character named Karen in Punisher comics. Usually, the main characters and well-known ones are pretty distinct, and I haven't come across a Karen in this series.