There are fanfictions where Issei leaves to protect others. He might learn of a great danger that is coming and decides that the best way to keep his friends and loved ones safe is to remove himself from the situation. So, he leaves, hoping that the enemy will follow him instead of targeting those he cares about.
One reason could be personal growth. Tony Stark is a complex character. In fanfiction, he might leave to explore his own identity outside of the Avengers. He could be seeking self - discovery, away from the constant superhero battles and group dynamics. He might want to focus on his own technological advancements or personal relationships without the interference of the Avengers' responsibilities.
Well, in fanfiction, the writers often explore different character arcs. Tony Stark could leave the Avengers because he wants to pursue a different path. He might have new goals that don't align with the Avengers' mission. For instance, he could be more interested in exploring new technologies for the betterment of the world on his own terms, without the constraints of the Avengers' group dynamic and decision - making processes.
It could also be that Snape represents everything that Harry hates about Hogwarts at that moment in the fanfiction. Snape's strictness, his partiality towards certain students, and his general unfriendly attitude might make Harry feel that Hogwarts is no longer the safe haven it once was. So, he leaves, thinking that he can find a better place where he doesn't have to deal with Snape's negative presence.
It could be that Garcia has some unresolved feelings for Morgan and can't handle seeing him get married. Or perhaps there's a conflict related to the preparations for the wedding that drives her away.
Perhaps he has some personal issues to deal with. Maybe he has received some news about his family (even though Jedi are not supposed to be attached, but they still have family ties in some sense). Or he could be having some doubts about the Jedi Order's actions in the war and needs time away to think.
Maybe Sam had his own urgent matters to attend to and couldn't stay with Bucky. Or perhaps he thought Bucky would be better taken care of by the friend in that situation.