Well, it gives a new take on the Spider - Man character. Instead of the traditional male hero, it focuses on a trans female. This allows for exploration of different experiences, like the character's relationship with her body in a superhero context. It also can bring in new storylines related to acceptance, both in the superhero community and in society at large.
Yes, there are some. You can start by looking on fanfiction platforms like Archive of Our Own. There you might find various interpretations of a trans female Spider - Man, which could explore different aspects such as her identity struggles within the superhero world, her relationships with other characters, and how she uses her powers in unique ways compared to the traditional male Spider - Man.
The Ultimate Spiderman TV show takes inspiration from the comics but makes changes to appeal to a wider audience and add new twists. While it retains the core of Spiderman, it's not a strict follow-up.
There was a recommended novel about transmigrating cells and cultivating immortality called "Cell Cultivation". This novel was a Xianxia/Cultivation novel, which included transmigration, prehistoric, interstellar, and technological cultivation elements. You can read this novel on Qidian Chinese website. The author is China's Jiao Zi, Giant Panda.