Some of the main villains in Insomniac Spider - Man 2 are Kraven the Hunter and Venom. Kraven is a formidable foe known for his hunting skills, and Venom brings his own unique set of challenges with his symbiotic powers.
Green Goblin is very memorable. His crazy laugh and the flying glider make him stand out. He has a complex relationship with Spider Man as Norman Osborn is also connected to Peter's personal life.
The Shriek can be really interesting in fanfiction. Her sonic powers can be explored in unique ways, like how she uses them not just for destruction but also to manipulate situations or people around Spider - Man.
The Lizard could be turned into a more supernatural villain. Maybe he gets possessed by an ancient spirit that makes him not only stronger but also able to control other reptiles with dark magic. This would pose a huge threat to Spider - Man as he has to deal with the Lizard's new powers on top of his already dangerous physical abilities.
The Vulture could be a new and more menacing villain. Maybe he's using the post - Civil War chaos to his advantage, stealing high - tech equipment that was left unguarded during the Avenger's split. He could be targeting Spider - Man specifically, seeing him as an easy target now that he doesn't have the full support of the Avengers.
For me, 'Spider-Man: Miles Morales' is a top pick. It brings a fresh perspective and focuses on a new hero while still staying true to the Spider-Man spirit. The art and writing are both top-notch.
There are quite a few Spider-Man comic series. It's hard to give an exact number as new ones are constantly being created and some older ones might be discontinued.