Sakura remains alive throughout the manga. The story doesn't have her character meet such a fate. Her role and presence continue until the end without her dying.
He may try to talk to Sakura and understand her reasons. Naruto is a character who believes in the goodness of people. So, instead of getting angry immediately, he would likely want to resolve the issue. He could also become determined to prove himself to Sakura, that whatever she thinks he has done wrong, he is actually not that person.
Well, it would have a huge impact. For Naruto, losing his sensei would be like losing a father figure. He'd be deeply saddened and might feel a bit lost in his ninja journey. The other characters like Shikamaru and Kiba would also be affected. They might start to question the safety of being a ninja. And the village as a whole would be in mourning. This could lead to a change in the village's dynamics, with more caution in sending ninjas on dangerous missions.
One theme could be grief and loss. Sakura would have to deal with the intense pain of losing her parents, which is a very common and relatable theme. It can show her journey through different stages of grief, like denial, anger, and acceptance.
Yes, there are storylines in some comics where Spiderman faces life-threatening situations and even appears to die, but often there are plot twists or resurrections.