Some writers characterize Acnologia as a misunderstood loner. They show that his actions of destruction are a result of his past traumas. Others might make him more of a power - hungry villain who just wants to rule over all. There are also those who give him a sense of humor, which is a very different take from his usual brooding and menacing self in the original series.
The plot involves Rimuru's journey from being a rather weak (initially) slime to becoming a very powerful being. He meets many interesting characters. For example, there are the goblins he befriends early on. Rimuru helps them improve their living conditions. As the story progresses, he also has to deal with the threat of other more powerful monsters and even some human kingdoms that view his growing power with suspicion. In general, it's a story full of adventure, growth, and the forging of relationships in a magical and dangerous world.
Well, adapting to Acnologia's body could be a complex process. They would have to learn how to control the raw power within it. This power might be overwhelming at first, and they could accidentally cause destruction. To adapt, they might start by testing their limits in isolated areas. Emotionally, they would also have to come to terms with the fact that they are now in the body of a feared being. They might try to use their memories of Fairy Tail to bring out the good in this new form, like using Acnologia's strength to protect the weak as they did in their previous life.
The main character is Rimuru Tempest. He is a slime who has unique powers and a great deal of charisma. Another important character is Veldora, the storm dragon who befriends Rimuru. There is also Shizu, a human who has an impact on Rimuru's early development. And then there are characters like Benimaru, a powerful ogre who becomes one of Rimuru's loyal followers.