Nebulized inhaled ventadimensional

Answer 1

Ventavir (Iloprost solution for inhalation) is indicated for the treatment of moderate primary pulmonary-artery hypertention.

In terms of dosage and administration, adults should start inhaling 2.5 micrograms each time (the dosage is provided through the mouth of the inhaling device), and the dosage can be gradually increased to 5.0 micrograms according to the patient's needs and tolerance. It should be inhaled 6 - 9 times a day, and each time it should be inhaled for about 5 - 10 minutes. For patients with kidney or liver incompetence (such as patients with abnormal liver function and kidney failure who require hemodynamics), the clearance rate of inoprost is reduced, and the dosage of inoprost should be considered for reduction. Children and teenagers (under 18 years old) currently have no experience in using it. Unless there is data to support it, it cannot be used on patients under 18 years old.

The standard for the usage of the Nebulizer was: the droplet's MMAD or MMD was 3 - 4 m; the output dose of the mouth-held device was 2.5 or 5 ug of eloprost per inhale; the time for a dose of 2.5 or 5 ug of eloprost to be vaporized was about 4 - 10 minutes (to avoid side effects, the output of eloprost within 4 minutes should not exceed 5 ug). In order to minimize accidental exposure, it is recommended to use a coalescer with a filter or an inhalation-triggering device when inhaling inoprost, and to maintain good ventilation in the room. The prepared solution is inhaled with appropriate equipment (coalescer).

In terms of adverse reactions, in addition to the local adverse reactions of inhaled drugs (such as worsening cough), it was mainly related to the pharmacology of prostacyclin. The most common adverse reactions in clinical trials included vasodilatation, headache, and worsening cough. very common adverse reaction (10 or more out of 100 patients may experience this): Hot flashes or redness of the face due to dilated blood vessels, increased coughing, low blood pressure (low blood pressure); Common adverse reactions (1 - 10 out of 100 patients) Headache, spasm of the cheek muscles (difficulty opening and closing mouth), fainting (Common symptoms of this disease. There was no significant difference in the frequency of syncope between the inoprost treatment group and the control group, but it may occur when using this drug); Other possible reactions include: If the patient takes anticoagulators (anticoagulators), a small amount of bleeding may occur (most patients with lung artery pressure take anticoagulators, and the common bleeding event is a hemorrhage. The frequency of bleeding in the inoprost group was not significantly different from that in the control group).

The taboos were as follows: Hypersensitivity to inoprost or any other vehicle; disease with increased risk of bleeding (For example, active digestive ulcers, trauma, cerebral hemorrhage or other bleeding), because the effect of this drug on blood plaque may increase the risk of bleeding; Patients with certain heart diseases, such as severe cardiac arrest, severe coronary-heart disease, unstable angina-pectori, myocardial-attack within 6 months of the onset of the disease, uncontrolled and treatment-less or not closely monitored uncompensated heart failure, congenital or acquired heart valve disease with clinical significant abnormalities of myocardial-function caused by non-pulmonary-artery-hypertention, and obvious pneumonedema with breathing difficulties; Patients who have had a stroke or other cerebral blood supply disorder in the past 3 months, or are pregnant or breast-feeding patients.

In terms of nursing care, psychological care should be done well for patients with lung artery hypertention who inhaled Vantavi. Communicate with the patient more and explain the drug performance, adverse reactions, and precautions for inhaled Vantavi. Take good care of the inhaled Vantavi. Each dose of Vantavi inhaled should be diluted and then vaporized to avoid wastage. After inhaling, hold your breath to strengthen the deposit and dispersion of the active ingredients. In order to avoid upright syncope, inhale the first dose of the drug every day when the patient is awake but not out of bed. The patient's condition and adverse reactions were closely observed. Vantavi had a hemodynamics effect, and the focus was on whether there were signs of low blood pressure, changes in the artery blood pressure, heart rate, and ultrasound index before and after inhaling Vantavi.

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