Colchiine for Gout

Answer 1

Colchiine is mainly used to treat acute episodes of gouty Arterial Cirrus and to prevent acute episodes of relapsing gouty Arterial Cirrus.

** I. Usage and dosage **
1. ** The acute stage **
- The usual dosage for adults was 0.5 - 1 milligram every 1 - 2 hours (if it was a 0.5 milligram tablet, one to two tablets could be taken accordingly) until the joint symptoms were relieved, or diarrhea or vomiting occurred. The treatment dose was usually 3 - 5 milligrams (about 6 - 10 tablets), and should not exceed 6 milligrams (12 tablets) within 24 hours.
- After stopping for 72 hours, the daily dosage was 0.5 - 1.5 milligrams (1 - 3 tablets), which was taken in portions for a total of 7 days.
2. ** precaution **
- 0.5 - 1 milligram (1 - 2 tablets) a day, divided into multiple doses, but the course of treatment should be determined according to the specific situation. If there are adverse reactions, the medicine should be stopped at any time.

- Currently, there is also a recommendation to use a small dose. Within 24 hours of acute gout attack, the first dose is 1.0 or 1.2 milligrams, and then 0.5 or 0.6 milligrams an hour later. 12 hours later, he started to take it regularly, 0.5 or 0.6 milligrams each time, 1 - 3 times a day, and the course of treatment lasted for 7 - 10 days.

** 2. Side effects **
1. ** Intestinal symptoms **
- Stomach pain, diarrhea, vomiting, and loss of appetite were common early adverse reactions, with an occurrence rate of up to 80%. In severe cases, it could cause symptoms such as dehydration and solute imbalance. Long-term use may result in severe bleeding gastroenteritis or malabsorption syndrome.
2. ** Muscle, peripheral neuropathies **
- There is a lack of muscle strength in the near end and/or an increase in the serum level of Creatine-Phosphatase. When muscle cells are damaged, there can be peripheral axonal polyneuropathy, which is manifested as numbness, tingling, and weakness. This situation is more likely to occur in people who take long-term medication to prevent gout and those with mild kidney incompetence.
3. ** Bone marrow suppression **
- Platelessness, a decrease in neutrons, and even aplastic leukemia may occur, which can sometimes be life-threatening.
4. ** Shock **
- The symptoms were oliguria, hematuria, convulsions, and disturbance of consciousness. The mortality rate was high, and it was more common in the elderly.
5. ** Teratogenic **
- It was reported in the literature that the fathers of 2 infants with Down syndrome had a long-term history of taking colquin due to familial Mediterranean fever.
6. ** Others **
- Hair loss, rashes, fever, and liver damage may also occur.

** 3. Taboo **
1. It is forbidden for people who are allergic to colchiine.
2. It is prohibited for patients with low bone marrow proliferations.
3. It is prohibited for patients with liver and kidney incompetence.
4. Pregnant women and breast-feeding women are prohibited, because colcicine can cause teratonia. Women of child-bearing age or their spouse should use effective contraceptive measures 3 months before the start of treatment, during treatment, and within 3 months after stopping the drug.

** 4. Points to note **
1. If severe reactions such as vomiting and diarrhea occur, the drug should be immediately stopped (according to the new instructions, when starting with a small dose, the drug should be immediately stopped if such adverse reactions occur; in the old instructions, the dose should be reduced if such reactions occur, and the drug should be immediately stopped if serious).
2. It should be used with caution in patients with bone marrow hemopoesis deficiency, severe heart disease, kidney incompetence, and digestive diseases.
3. During the medication period, the hemogram and liver and kidney functions should be checked regularly.
4. Do not increase or decrease the dosage on your own, because excessive use of colchiine can cause serious digestive reactions, bone marrow suppression, liver and kidney function damage, etc. There is currently no specific antidote and cannot be removed through hemohemodia.
5. Do not drink alcohol when taking the colchiine tablets to avoid increasing the side effects of the drug.
6. If headache, dizziness, depression and other symptoms affecting the central nervous system occur, the drug should be stopped immediately.
7. Elderly people should reduce the dosage, because the amount of colchiine poisoning is often related to the accumulated dose in the body. When the kidney secretion function is reduced, it is easy to cause accumulation of poisoning. Moreover, colchiine needs to be detoxified through the intestinal liver circulation. When the liver function is poor, the detoxification ability is reduced, and it is easy to aggravate the toxicity.
8. Children's medication: This experiment has not been conducted and there are no reliable references.