The main drugs that inhibited the production of uric acid were allopurinol, febustat, topistat, ulodesine (BOx- 4208), probenecid, etc. Allopurinol suppresses the production of uric acid through the inhibition of the oxanthine oxidoxases; Febustat is a selective oxanthine oxidoxases inhibition drug that can reduce serum uric acid; Topicastat is a new non-purine oxanthine oxidoxases inhibition drug; Ulodesine is a non-purine oxanthine oxidoxases inhibition drug.[BOx- 4208] suppresses the production of uric acid by suppressing the activity of purine chopstick Phosphorase upstream of the Xanthine Oxidases. Probenecid suppresses the production of uric acid and increases the secretion of urates, thereby reducing the concentration of urates in the blood. Read more exciting novels for free
There were mainly the following types of drugs for the treatment of elevated blood uric acid: 1. ** Uric acid synthesis suppressing drug **: - ** Allopurinol **: It is used earlier and can effectively suppress the production of both the enzyme and the enzyme, thereby reducing the production of uric acid. It can be used for hyperuricuria due to excessive production of uric acid, repeated attacks of gout, tophi, and other conditions. However, it is prohibited for people with severe liver and kidney function damage and obvious low blood clot. People who are positive for HLA-B5801 may have severe allergic reactions. The positive rate of this gene is higher in Asian people. It is recommended to do a genetic test before taking it. If it cannot be detected, start taking it from the minimum dose. - ** Febustinat **: It is a selective yellowine oxi dase inhibition drug. It is suitable for hyperuricuria caused by gout. It is not recommended for people with hyperuricuria without symptoms of gout. The US Food and Drug Administration suggests that taking it may increase the risk of cardiovascular death. People at risk of cardiovascular disease need to be evaluated by a doctor before taking it. 2. ** Uric acid expelling drug **: - ** Benbromarone **: It can block the reabsorption of blood uric acid by the kidney tubulae and correct the situation of insufficient blood uric acid secretion in the kidneys of patients with hyperuricemia. It is used for people with kidney failure with a clearance rate of more than 20ml/min, but it is prohibited for patients with acute gout, severe kidney function damage, or severe kidney stones. When taking it, drink a lot of water (more than 3000ml of water per day). Pay attention to liver function when taking the medicine. Discontinue the medicine immediately when there is loss of appetite, nausea, vomiting, and diarrhea. - ** Probenecid **: Only used in people with primary hyperuricuria with normal kidney function. 3. ** New uric-lowering drugs **: For example, Rasburicase, which belongs to the uricase class, can decompose uric acid into a dissolved product and discharge it. However, it is prohibited for people who are allergic to this product, pregnant women, and G6PD-deficient people. There may be adverse reactions such as fever, nausea, vomiting, and rashes. 4. ** Alkaline urine medicine **: For example, it can be used when the urine is slightly acidic. In addition, there were also some Chinese medicines that could help reduce blood uric acid. For example, Plantago Seed and Alisma in Tongfengding capsules could accelerate the secretion of uric acid. Huangbai and Smilax glabra could remove dampness and detoxify. Red peony could help with blood stasis and pain. Cyathula and Corymphala could dispel wind and dampness, dredge the channels and promote blood circulation, regulate qi and relieve pain. Qinjiao could dispel dampness, clear damp heat, and stop arthralgia. It is recommended to consult a doctor about the specific medicine to be used. Under the doctor's guidance, it should be used according to the doctor's advice. <a href="/?from=ask_words" style="color:red" target="_blank">Read more exciting novels for free</a>
The following factors may be related to the repeated attacks of gout after taking uric-acid-lowering drugs: 1. ** Didn't take the medicine according to the doctor's advice **: - If the medication time is short or the dosage is insufficient, it is difficult to achieve the pharmacology effect. The body is still in a state of high blood uric acid. If it is not effectively controlled for a long time, it will lead to frequent attacks of gout. - Some patients took uric-acid-lowering drugs on their own without considering the adverse reactions and dosage issues. The first time they took uric-acid-lowering drugs, it might cause the uric-acid crystals in the joint cavity to suddenly disintegrate. The surrounding engulfing cells would be attracted to try to devour the uric-acid crystals, thus releasing a large number of inflammatory factors, leading to acute inflammation of the joint. 2. ** Uric acid lowering speed problem **: - Uric acid lowering treatment should be a long-term, slow process, and the rate of decrease of UA should be stable. Some patients were eager to reduce their blood uric acid levels to normal levels in a short period of time. They increased the oral dosage of uric-acid-lowering drugs without authorization, or took multiple uric-acid-lowering drugs at the same time, which may cause repeated attacks of gout. - During the process of lowering UA, the effect of the drug may cause UA to drop rapidly, which may cause a relapse of gout, especially at the beginning of UA reduction. This situation may be called "crystal pain" or "secondary gout". For example, it was more likely to appear in patients with uric acid crystals deposited in the joints or tophi. 3. ** Bad living habits **: Smoking and drinking, eating a large amount of seafood, animal internal organs, etc. will cause excessive purine intake in the body, causing the body's blood uric acid to rise, which will lead to repeated attacks of gout. If this happens, the following measures can be taken: 1. ** Don't stop the medicine at will **: When the gout flares up during the uric-acid lowering process, stopping the uric-acid-lowering medicine treatment will be a waste of previous efforts. Even if there was "crystal melting pain", it proved that the uric-acid-lowering drug had played a role in reducing uric acid and dissolving uric acid crystals. At this time, the drug was stopped, and the uric acid crystals originally deposited in the joints and other parts had not been completely dissolved or even eliminated. At the same time, sudden withdrawal of the drug would also cause the blood urine level to rise rapidly, which may lead to the onset of acute gouty arthrosis. It may also increase the deposit of uric acid crystals, which is not conducive to the recovery of the disease. It may even promote the growth of tophi. 2. ** Pain Treatment **: - When a gout attack occurs, you can consider increasing the use of corresponding painkillers, such as colchiine, small doses of non-steroid anti-inflammatory painkillers, or small doses of steroids. However, it is recommended to consult a doctor about the specific types of drugs and dosage. - For the first six months of the initial UA reduction, a small dose of painkillers, such as non-steroid anti-inflammatory drugs or a small dose of colchiine, can be added. 3. ** Adjusting the dosage of the medicine to lower UA acid **: - At the beginning of taking the uric-acid-lowering drug, start with a small dose (you can confirm it according to the instructions or communicate with the doctor), and then increase the dose every half a month or one month (usually start with half a tablet, add half a tablet each time) until the uric-acid reaches the standard or increases to the standard dose. - For example, the dosage of febustinat should start from 20 milligrams. After about 4 weeks of medication, check whether the blood uric acid level is up to standard. If it is up to standard, continue to maintain it. If it is not up to standard, increase the dosage, but it should not exceed 80 milligrams per day. 4. ** Lifestyle adjustment **: - It is recommended that during the uric-acid-lowering treatment, lifestyle conditioning should be carried out, such as drinking more water, avoiding high purine diet (such as seafood, animal internal organs, etc.), keeping your mouth shut, losing weight, moving your legs, and carrying out low-to-medium-intensity cardiovascular exercise. <a href="/?from=ask_words" style="color:red" target="_blank">Read more exciting novels for free</a>
Colquin tablets couldn't lower UA. Colchiine was mainly used to treat acute episodes of gouty Arteritis and prevent acute episodes of relapsing gouty Arteritis. It had anti-inflammatory and pain-relieving effects.
The following foods are thought to help lower uric acid levels: celery, kiwifruit, steamed buns, eggs, seaweed, milk, cucumbers, tomatoes, corn, cherries, coffee, fruits and vegetables, milk products, and vitamins. Some of these foods contain an acidic substance that can promote the dissolution and discharge of uric acid. In addition, some foods are rich in potassium, which has a diuretic effect and helps in the discharge of uric acid. However, it should be noted that diet control is essential to reduce the level of uric acid. It is necessary to avoid eating foods with high purine content, such as meat, seafood, animal internal organs, etc.
The gardenia tea could lower UA. The extract of gardenia could lower blood uric acid and suppress the activity of the hawthorn. The geniposide contained in it could also promote the secretion of uric acid. Therefore, gardenia was a medicinal and edible plant that could not only suppress the production of uric acid, but also promote the expression of uric acid transporter and promote the secretion of uric acid. The novel " Smelling the Jasmine Fragrance Again " is equally exciting. Everyone is welcome to click and read it!
If it is due to depression, anxiety and other psychological factors that cause depression and irritability, you can take antiderents such as paroxi tablets, venlafaxine tablets, and duloroxi capsules. You can also use them in combination with alprazolan and clonazepam for a short period of time. He could also use traditional Chinese medicine that could nourish the heart and calm the mind, such as Jiuwei Zhenxin Granules, Anshen Bunao Liquid, Shugan Jieyu capsules, as well as mood stabilizing agents such as magnesum valproate, olanzo, quetiiping fart, flupenthixol and melitracen, as well as nutritional drugs such as vitamins B1 and oryzantine. If it was depression caused by liver qi stagnation, restlessness, palpitations, insomnia, and dreams, you could use Jieyu pills under the guidance of a doctor. Tandospirone Citrate capsules could also fundamentally reduce anxiety. In addition, the white peony root in the field of traditional Chinese medicine had the effect of calming the liver and suppressing yang, nourishing the blood and softening the liver, and could relieve depression and irritability. Ten grams of white peony root could be boiled after adding three grams of green tea, and then drunk after cooling down (not suitable for people with deficiency of the spleen and stomach). <a href="/?from=ask_words" style="color:red" target="_blank">Read more exciting novels for free</a>
The fastest way to reduce uric acid in mulberry leaves was to drink a cup of tea brewed with chrysanthemum, gardenia, mulberry leaves, lily, and root of Kudzu vine every day for a month. This method can help reduce the level of uric acid.
People with a high level of Dictyoporus acid could eat it in appropriate amounts. Bamboo fungus was an edible fungus. The purine content in every 100 grams of bamboo fungus was 0-25 milligrams, which was a food with low purine content. For people with high uric acid, it was mainly because of the disorder of purine metabolism in the body, so they needed to limit the intake of high-purine foods. Bamboo fungus is rich in protein, vitamins, and minerals. It can supplement the nutrients needed by the body in an appropriate amount and help maintain the normal physiological functions and metabolism of the body. Although bamboo fungus itself did not have the effect of directly reducing uric acid, moderate consumption was safe for people with high uric acid. However, for those who are allergic to bamboo fungus and those with weak spleen and stomach, it is not advisable to eat bamboo fungus. In general, people with high uric acid can eat bamboo fungus in an appropriate amount, but they should pay attention to moderate control and avoid excessive eating to avoid increasing the burden on the digestive tract.
There were different opinions on whether gardenia tea could lower uric acid. Some studies had found that gardenia extract could lower blood uric acid, geniposide could promote the secretion of uric acid, gardenia tea could promote the secretion of uric acid by increasing urine, and there were records that cicadas and gardenia could help lower uric acid. However, there are also opinions that gardenia tea does not have a clear effect of reducing uric acid. At present, gardenia or its extract has not been found to have a clear effect of uric acid. Patients with high uric acid are not recommended to blindly use gardenia and other Chinese medicinal herbs soaked in water. It is recommended to be diagnosed and treated under the guidance of professional doctors. The novel " Smelling the Jasmine Fragrance Again " is equally exciting. Everyone is welcome to click and read it!
Birch sap had the mechanism of reducing uric acid and relieving gout, but no information had been found about the effect of birch branches on reducing uric acid, so it was uncertain whether birch branches could reduce uric acid. "Life Like a White Birch" is equally exciting. Everyone is welcome to click and read it!