There's a target, but taking targeted drugs doesn't work.
There might be the following reasons why the targeted drug had no effect: 1. Non-genetic mutant lung cancer: targeted therapy is mainly used for patients with genetic mutations, such as mutations in EGFR and ALK. If it is not a genetic mutant lung cancer, the success rate of targeted therapy is very low. 2. Unmatched targets: The principle of targeted therapy is to target the mutated genes of cancer cells and kill the cancer cells selectively. If the target is not correct, the targeted therapy will be ineffective. 3. Multiple Metastases of Lung Cancer: If the lung cancer is already advanced and there are multiple organ metastasies, symptoms such as worsening of the disease may occur at the metastasized site, resulting in poor efficacy of the targeted drug. 4. Drug resistance: After a period of targeted treatment for lung cancer, drug resistance may occur, resulting in ineffective treatment. 5. Gene mutation abundance: Even if the same gene mutation or even the same gene mutation, the difference in gene mutation abundance may lead to differences in treatment effects. Gene mutation abundance generally refers to the relative or absolute quantitative value of mutant EGFR mutant genes. Different values may affect the efficacy of targeted drugs. The specific reason for the ineffectiveness needed to be determined by the doctor based on the patient's general condition and related examinations. Read more exciting novels for free
What are the effects of taking targeted drugs in the late stage of liver cancer?
There may be the following symptoms when taking targeted drugs for late-stage liver cancer: - If the condition was under control and the tumor growth was suppressed, the tumor might shrink. - For patients with late-stage liver cancer who developed ascitic fluid, if their stomachs gradually subsided after taking the targeted drug, it might mean that the ascitic fluid decreased and the condition was controlled to a certain extent. - The patient's condition was stable. For example, although the tumor did not shrink after taking the targeted drug, its growth rate slowed down. <a href="/?from=ask_words" style="color:red" target="_blank">Read more exciting novels for free</a>
Late stage liver cancer, taking targeted drugs, black stool discharge
There may be many reasons for black stool discharge in patients with late-stage liver cancer when taking targeted drugs. The following is the specific analysis and countermeasures: ##1. Reason Analysis 1. ** Drug factor ** - The targeted drug may cause bleeding in the digestive tract. The hemoglobinin the blood will turn black after digestion in the intestine, resulting in black feces. 2. ** Disease-related factors ** - Patients with late-stage liver cancer may have coagulated due to tumor invasion of the liver, which may lead to digestive tract bleeding. In addition, bleeding from the ruptured esophagus and gastric varices caused by portal vein hypertention was also a common cause. 3. ** Dietary factors ** - Although it is rare, eating too much black food recently (such as mulberries, animal blood products, etc.) may also cause the color of the stool to turn black. ##2. Treatment 1. ** See a doctor immediately ** - After black stool appears, the patient should immediately seek medical attention and describe the symptoms and medication to the doctor in detail. 2. ** Complete relevant checks ** - The doctor may arrange for a stool occult blood test, a colonoscopy, and other examinations to determine if there is any bleeding in the digestive tract and its cause. 3. ** Adjusts treatment plan ** - According to the results of the examination, the doctor may adjust the dose of the targeted drug or change the drug to reduce the risk of digestive tract bleeding. 4. ** Bleeding control treatment ** - If a diagnosis of digestive tract bleeding was confirmed, the doctor might give hemostatic drugs (such as vitamins K1, tranexamic acid, etc.) to promote the synthesis of blood clot factors and reduce bleeding. 5. ** Protect gastric mucus ** - The damaged liver function of patients with late-stage liver cancer may affect the secretion and secretion of bile, causing bile to flow back into the stomach and cause damage to the gastric mucus. At this time, you can use a protective agent for the digestive tract (such as aluminum magnesite, sucralfate, etc.) to neutralize gastric acid and protect the gastric mucus. 6. ** Nutritional support ** - Patients with late-stage liver cancer were usually in poor physical condition, and nutritional supplements (such as compound aa, fat milk, etc.) could provide the necessary nutrients to support the patient's recovery process. 7. ** Pay attention to rest ** - The patient should pay attention to rest and avoid overwork to avoid increasing the burden on the liver. In short, the blackness of patients with late-stage liver cancer during targeted drug therapy was a symptom that needed to be taken seriously. Patients should pay close attention to the changes in their symptoms. If they have persistent black stool or other discomfort symptoms, they should inform the doctor in time. At the same time, they should maintain good eating habits, avoid eating food that may increase the burden on the stomach and intestines, and follow the doctor's advice for treatment and adjustment. <a href="/?from=ask_words" style="color:red" target="_blank">Read more exciting novels for free</a>
Take the third generation of targeted drugs after the first generation of targeted drugs are resistant
After the first-generation targeted drug became resistant, the third-generation targeted drug could be considered. According to the data in document [2], after the first-generation targeted drug became resistant, only about 25% of patients had the opportunity to use osimertinib for second-line treatment. According to the study mentioned in document [4], the first-line use of osimertinib for the treatment of egfr-positive lung cancer, followed by comprehensive treatment methods such as chemotherapy and chemotherapy after drug resistance, the patient's overall survival time was 41.4 months, which was twice as long as the first-generation targeted drug. In addition, the document [5] mentioned the dual-target combination therapy plan, specifically the first-line treatment of the third-generation TKi osimertinib combined with the first-generation TKi gefitini, with a disease control rate of 100%. Therefore, for patients who were resistant to first-generation targeted drugs, third-generation targeted drugs might be an effective treatment option.
What are the targeted drugs that need to be tested?
In cancer treatment, genetic testing was usually needed to find suitable targets to determine whether targeted drugs could be used. For example, targeted drugs corresponding to mutations in genes such as EGFR, ALK, ROS - 1, BRAF, etc. in lung cancer needed genetic testing to determine the existence of the target before use. In addition, genetic testing was also needed to determine whether cetuxed could be used in the treatment of patients with benign or malignant tumors. However, targeted drugs such as domestic anlotinib, lenvatini, regorafenib, sorafenib, apitini, sunitini, cabotini, cediranil, bevacizumi, and olakumab, as well as bevacizumi in head and neck tumors (such as throat cancer, oral cancer, gum cancer, and other pathological squamous-cell cancer), did not require genetic testing. However, in general, it was more complicated to perform target testing for different tumor diseases and targeted drugs before use. It needed to be analyzed according to the specific situation. <a href="/?from=ask_words" style="color:red" target="_blank">Read more exciting novels for free</a>
What are the types of targeted drugs in Henan?
It was known that 17 targeted drugs, including osimertinib, crizotinib, anlotinib, and afartinib, had entered the scope of reimbursement for Henan medical insurance, but it was impossible to determine all types of targeted drugs in Henan based on the available information. However, the common targeted drugs were the first-generation gefitini and erlotini, the second-generation aflatini and dacomitini, and the third-generation osimertinib. Monocentric antibody-type molecular targeted drugs such as trastuzumb (Herceptin), Rituexiu (Mebthera), EMC-C225 (cetoxieb, Erbitux), and Bevacizu (Avastin). Small molecular compounds were commonly used, such as Glivec (ST51, Imatini), Iressa (ZD1839, Gefitini), and OSI774 (Erlotini, Tarcava). <a href="/?from=ask_words" style="color:red" target="_blank">Read more exciting novels for free</a>
What are the targeted drugs for serous adenomas?
For high-grade serous adenomas, targeted therapy includes anti-neoplastic targeted drugs such as bevacizumi; for relapsed low-grade serous adenomas, Novartis targeted anti-cancer drug Mekinist (Trametini) has the potential to become a treatment option. In addition, in the treatment of malignant tumors, nirapalide tosylate capsules can be used as a targeted drug for maintenance therapy. For patients who overexpress HEL2/ neu, adding trastubiza (Herceptin) to standard chemotherapy can provide a new solution to improve the prognosis. <a href="/?from=ask_words" style="color:red" target="_blank">Read more exciting novels for free</a>
What should I do if I have a digestive tract reaction after taking targeted drugs?
The digestive tract reactions after taking targeted drugs can be handled in the following ways: 1. ** General care ** - Pay attention to food hygiene and prevent infection of the digestive tract. - Make sure to drink about 3000ml of water every day to replenish the water lost from diarrhea. - If there is diarrhea, guide and help the patient to wash the perianus skin in time after defecation, do a good skin care, and protect the patient from fainting. 2. ** For oral mucus problems ** - Because oral myozotis can cause the body's resistance to decrease again, it is easy to cause bacteria or fungus infection. You can give 5% solution of NaH 2 CO 3 and compound clorhexine to rinse your mouth. - When an oral sore occurs, you can apply oral sore jelly or use Jin Yin Peptide spray to reduce pain and promote the healing of the sore surface. 3. ** In case of digestive tract rupture (this is a more serious case)** - Stop the medication: Once the targeted drug is confirmed to be the cause of digestive tract rupture, stop the medication immediately and inform the doctor of the name of the drug used so that the doctor can diagnose and treat it. - Stomach emptying: The liquid and gas in the stomach are pumped out through the stomach tube to reduce the pressure in the stomach and relieve the symptoms. - Anti-infective treatment: The digestive tract is prone to abdominal infection, requiring the use of antibiotics for anti-infective treatment. - Surgery: If the hole is small, it can be repaired by laparoscopy; if the hole is large or the condition is serious, open surgery is needed to repair the hole and clean the abdominal cavity. - Supporting treatment: including intravenous fluids, nutritional support, etc., to maintain the patient's vital signs and bodily functions. 4. ** For diarrhea (when caused by multiple causes)** - If the drug reaction caused severe diarrhea, one should pay attention to light diet, avoid irritating food intake, and appropriately increase the amount of water consumed. It can also be treated with smectite powder under the guidance of a doctor. - If it is caused by indigestion (targeted drugs may stimulate the digestive system), to avoid the intake of cold and greasy food, you can take drugs such as pandolone and probiotic bacteria to promote digestion under the guidance of a doctor. - If it was diarrhea caused by enteritis, the patient should avoid overwork, increase the amount of water to avoid dehydration, and use berberine and other drugs under the guidance of a doctor. <a href="/?from=ask_words" style="color:red" target="_blank">Read more exciting novels for free</a>
There are several types of breast cancer targeted drugs
There were mainly the following types of breast cancer targeted drugs: 1. Anti-neoplastic targeted drugs: There are intravenous preparations and oral drugs, but the effect in the treatment of breast cancer is not ideal. For example, bevacidol (Avastin) will be considered in some cases. 2. Anti-Her- 2 targeted drugs: targeted at HER - 2 positive patients, it is the most important targeted drug for breast cancer, mainly including trastuzumab (Herceptin), pertubizab, dm- 1, lapatini, etc. The prerequisite for use was that the patient was positive for HER - 2 (+++ in the immune tissue test). If the immune tissue test was ++, the patient would need to undergo a further FISH test. The patient could only be used if the FISH test was positive. If the immune tissue test was + or-, the patient could not be used. 3. A targeted drug for patients with fetal mutations in the Brca lineage: The main drug is olaparib, which is used to treat patients with metastasizing breast cancer who have harmful or suspected harmful mutations in the Brca lineage and who are negative for the human embryonic growth factor receptor 2 (HEL2). 4. Immune therapy (in a sense, it was also a targeted drug): Anti-PD- 1/PD-L1 Monoclone Antibodies, which essentially relieved immune suppression and activated immune cells to kill cancer cells. 5. mTO inhibition drugs, such as everolimus and sirolimus, can inhibit the activation of the mTO signaling pathway, thereby suppressing the growth and metabolism of tumor cells. 6. Other targeted therapy drugs, such as Parp inhibition drugs, CD 4/6 inhibition drugs, etc. <a href="/?from=ask_words" style="color:red" target="_blank">Read more exciting novels for free</a>
Is it always effective to take targeted drugs for lung cancer?
The effect of targeted drugs on lung cancer patients was not very good. Target drugs could not cure lung cancer. Although they could prolong survival time, they could not always be effective. There were very few driver mutations in lung cancer, so there were relatively few targeted drugs that could be used. When using targeted drugs, it was necessary to find the target of lung cancer and could not be used blindly. <a href="/?from=ask_words" style="color:red" target="_blank">Read more exciting novels for free</a>
What targeted drugs can be taken for oral cancer?
The targeted drugs for oral squamous-cell cancer included pabolizumab injection, trastubizab for injection, erlotinib, gefitinib, cetuxed, nivaliumab, etc. Pabolizub injection can be used to treat advanced non-small cell lung cancer, advanced gastric cancer, oral Squamoma, etc.; Trastuzu for injection can be used to treat metastasized breast cancer, metastasized gastric cancer, oral Squamoma, etc.; Erlotinib is suitable for patients with advanced non-small cell lung cancer who have a mutation in Exon 19 or L858 of the Epidermal growth factor receptor Tyrosin Kinase gene. It can block the egf-signaling pathway to inhibit the growth of tumor cells; Gefitini can be used for the treatment of patients with locally advanced or metastasized non-small cell lung cancer who have failed at least one previous chemotherapy program. It can selectively inhibit the activity of EGFR protein protein. Cetuxed is suitable for the auxiliary treatment of RAS gene wild-type Colon Cancer, Rectal Cancer, and Stomach Cancer. It can be used in combination with radiation to improve the efficacy. Nivaliumab is suitable for the treatment of patients with advanced liver cancer who have failed previous systematic treatment. It activates T cells, allowing them to recognize and attack tumor cells that express the PD - 1 receptor. When using these drugs, you must follow the doctor's advice and pay attention to their respective conditions and precautions. <a href="/?from=ask_words" style="color:red" target="_blank">Read more exciting novels for free</a>