Is there anyone who is not resistant to targeted drugs for a long time?
Yes, the drug resistance of targeted drugs varied from person to person. Some people could take it for seven or eight years without resistance, but not everyone would develop drug resistance within a fixed period of time. Read more exciting novels for free
Take the third generation of targeted drugs after the first generation of targeted drugs are resistant
After the first-generation targeted drug became resistant, the third-generation targeted drug could be considered. According to the data in document [2], after the first-generation targeted drug became resistant, only about 25% of patients had the opportunity to use osimertinib for second-line treatment. According to the study mentioned in document [4], the first-line use of osimertinib for the treatment of egfr-positive lung cancer, followed by comprehensive treatment methods such as chemotherapy and chemotherapy after drug resistance, the patient's overall survival time was 41.4 months, which was twice as long as the first-generation targeted drug. In addition, the document [5] mentioned the dual-target combination therapy plan, specifically the first-line treatment of the third-generation TKi osimertinib combined with the first-generation TKi gefitini, with a disease control rate of 100%. Therefore, for patients who were resistant to first-generation targeted drugs, third-generation targeted drugs might be an effective treatment option.
What are the drugs that are resistant to long-term use?
The main types of drugs that might develop resistance after long-term use were the following: 1. [Antibiotic: It is a misunderstanding for many people to use antibiotics when they catch a cold because most colds are caused by viruses. Antibiotic is ineffective against viruses, and the abuse of antibiotics will cause more bacteria in the body to come into contact with antibiotics, increasing the bacteria's resistance.] Moreover, antibiotics were prescription drugs, so there were technical requirements for their use. Self-medication could easily lead to medication errors, which was also an important reason for bacteria resistance. 2. ** Antihypertensives **: When some antihypertensives such as pulicept or sartan are used for a long time in some patients, the aldosterone level in the body will first decrease and then increase (aldosterone escapes), which will cause blood pressure to be difficult to control. 3. ** Antihyperbaric drugs **: Sulfonylureas reduce blood sugar by stimulating B cells in the islets of Langerhans to secrete hormone. When the function of B cells in the islets of Langerhans is exhausted, the drug will lose its effectiveness. This type of drug is only suitable for patients with diabetes who have secretion function in the islets of Langerhans. 4. ** Sleeping pills **: tranquilizers and new types of non-benz-azepines are easy to tolerate in the long term. They often need to be increased in dosage and can also cause dependence. Therefore, as a psychiatric drug, they need to be taken on demand, intermittently, and for short periods. 5. ** Asthma inhalers **: The short-acting inhalers are easy to be tolerated and ineffective after long-term use. They should be used in the smallest dosage and the least number of times as needed. The inhalers can be stopped when the symptoms are relieved. 6. ** Painkillers **: When patients with chronic pain use painkillers for a long time, they need to increase the dosage to effectively relieve pain, but they cannot increase the dosage privately. Some painkillers have a "cap effect", and overdosage is easy to be poisoned. Opioid painkillers are controlled due to addiction. Before the application of painkillers, a specialist should assess the degree of pain and use the painkiller according to the "three-step pain relief principle". 7. ** Nose Drops **: Long-term use of nasal mucus constrictors (such as anesthetic) will cause rebound expansion of nasal mucus vessels, aggravate nasal obstruction symptoms, and even damage nasal mucus, causing drug-induced rhinoceros. It may also induce high blood pressure. It is generally used to relieve acute symptoms. It should not be used for more than 7 days in a row and not more than 3 times a day. <a href="/?from=ask_words" style="color:red" target="_blank">Read more exciting novels for free</a>
What are the targeted drugs for immunity drugs?
The immune drugs mainly included nivulumab injection, pabolizuab injection, atilibizab, duvalliumab, carrelizub, etc. The targeted drugs mainly included trastubiza for injection, pertubiza injection, osimertinib, dacotinib, gefitini, erlotinib, icotinib, afartinib, etc.(There were also many targeted drugs for different cancer types, such as osimertinib and dacotinib targeted for the first-line treatment of lung cancer and lung cancer, alectinib, crizotinib, etc. for the first-line treatment of ALK mutation). <a href="/?from=ask_words" style="color:red" target="_blank">Read more exciting novels for free</a>
How long will it take for targeted drugs to be effective for lung cancer?
Patients with lung cancer usually took targeted drugs for ten days, no more than forty days, and the effect would take effect in two to three days. <a href="/?from=ask_words" style="color:red" target="_blank">Read more exciting novels for free</a>
What are the benefits of targeted drugs?
The targeted drugs had the following benefits: 1. Strong treatment targeting: From the molecular level of cells, drugs are designed to target specific targets on the surface of cancer cells, and more accurately act on the target to control the tumor. They only act on the target and have little effect on normal cell tissues. 2. It has remarkable efficacy: it can effectively kill tumor cells and reduce lumps. In some patients, its efficacy is no less than that of chemotherapy and chemotherapy. It can reduce the symptoms of cancer patients, improve the survival time and quality of life of cancer patients, and make cancer a chronic disease that can be treated continuously to a certain extent, helping patients survive with cancer. 3. Less side effects: Because it has little effect on normal cells and tissues, there are fewer side effects. Compared to treatments such as chemotherapy, there are no side effects of chemotherapy. For example, it will not cause large-scale destruction to normal cells in the body like chemotherapy. <a href="/?from=ask_words" style="color:red" target="_blank">Read more exciting novels for free</a>
Is it useful to take targeted drugs after chemotherapy and discharge? How long?
Compared with traditional chemotherapy drugs, anti-tumor targeted drugs had a completely different mechanism of action. At the same time, they had the significant advantages of high efficiency, low toxicity, and strong specialization. It was useful to use targeted drugs after discharge from chemotherapy, but the specific duration of effect would be affected by many factors. The drug resistance of targeted drugs was an important factor that affected their duration of action. Cancer cells would mutate. Although targeted drugs could accurately attack cancer cells, they could not identify all cancer cells in all directions. It was easy for drug resistance to occur. When cancer cells develop drug resistance, the effect of the targeted drug will decrease, and at this time, the drug may need to be changed. In order to detect drug resistance problems in time, regular assessment tests, such as tissue examination and blood test, were needed to adjust the medication in time. The individual differences between different patients would also affect the duration of the targeted drug. For cancer patients with specific gene mutations, such as cancer patients with egf-mutation, the targeted drug treatment effect would be more prominent, and the drug efficiency could reach 70%. Before targeted therapy, a comprehensive assessment was needed to understand whether there were specific changes in the genes. Patients who met the conditions would have a better effect if they used targeted drugs. In addition, the way the targeted drug was taken would also affect its effect and duration of effect. For example, the drug should be administered at the same time every day. This would allow the targeted drug to release a stable concentration of the drug, allowing the human body to absorb the drug's effects more deeply. If the timing of taking the medicine was messed up, the concentration of the medicine could not be released stably, which might affect the treatment effect. In short, taking targeted drugs after hospitalization was useful, but it was difficult to determine how long it would last. It was necessary to consider various factors such as drug resistance, individual differences, and medication methods. <a href="/?from=ask_words" style="color:red" target="_blank">Read more exciting novels for free</a>
How long do you take targeted drugs for lung cancer?
The time taken for targeted treatment of lung cancer needed to be considered from both the patient's own condition and the progression of the disease. For patients with middle-stage lung cancer, it is recommended to take the first-generation targeted drug for 1.5 - 2 years or the third-generation targeted drug for 3 years. For patients with advanced lung cancer, as long as the targeted drug was effective, it was recommended to take it until the disease progressed. If drug resistance appeared, the targeted drug would need to be replaced. However, it should be noted that the premise of using targeted drugs was that the patient must have a clear target for treatment in the body, and there must be a specific drug targeting the target before targeted drug therapy could be carried out. Less than 20% of lung cancer patients could find targeted drugs. <a href="/?from=ask_words" style="color:red" target="_blank">Read more exciting novels for free</a>
How long will it take to take targeted drugs after chemotherapy and discharge?
The targeted medicine usually took effect in three to four weeks, but the specifics varied from person to person. Some took effect in a few days, while others took months to see obvious effects. If the target was clear and the patient was more sensitive to the drug, the obvious effect might be seen in 2 - 3 days after taking the drug, and the clinical symptoms would be significantly improved. If the target was unclear or the patient was not sensitive to the drug, the effect would be slower. It might take 2 - 3 months to see the effect, but most patients could improve their symptoms in 3 - 4 weeks after taking the drug. <a href="/?from=ask_words" style="color:red" target="_blank">Read more exciting novels for free</a>
What are the types of targeted drugs in Henan?
It was known that 17 targeted drugs, including osimertinib, crizotinib, anlotinib, and afartinib, had entered the scope of reimbursement for Henan medical insurance, but it was impossible to determine all types of targeted drugs in Henan based on the available information. However, the common targeted drugs were the first-generation gefitini and erlotini, the second-generation aflatini and dacomitini, and the third-generation osimertinib. Monocentric antibody-type molecular targeted drugs such as trastuzumb (Herceptin), Rituexiu (Mebthera), EMC-C225 (cetoxieb, Erbitux), and Bevacizu (Avastin). Small molecular compounds were commonly used, such as Glivec (ST51, Imatini), Iressa (ZD1839, Gefitini), and OSI774 (Erlotini, Tarcava). <a href="/?from=ask_words" style="color:red" target="_blank">Read more exciting novels for free</a>
What are the targeted drugs that need to be tested?
In cancer treatment, genetic testing was usually needed to find suitable targets to determine whether targeted drugs could be used. For example, targeted drugs corresponding to mutations in genes such as EGFR, ALK, ROS - 1, BRAF, etc. in lung cancer needed genetic testing to determine the existence of the target before use. In addition, genetic testing was also needed to determine whether cetuxed could be used in the treatment of patients with benign or malignant tumors. However, targeted drugs such as domestic anlotinib, lenvatini, regorafenib, sorafenib, apitini, sunitini, cabotini, cediranil, bevacizumi, and olakumab, as well as bevacizumi in head and neck tumors (such as throat cancer, oral cancer, gum cancer, and other pathological squamous-cell cancer), did not require genetic testing. However, in general, it was more complicated to perform target testing for different tumor diseases and targeted drugs before use. It needed to be analyzed according to the specific situation. <a href="/?from=ask_words" style="color:red" target="_blank">Read more exciting novels for free</a>