It could be a simple lovers' quarrel. Maybe the man did something wrong and the woman is fed up and leaving.
Perhaps it's a scene of unrequited love. The man confessed and was rejected, so the woman walks away. Or maybe they have different goals or dreams that can't be reconciled, causing her to depart.
Perhaps it indicates that the man and woman are ascending to a state of angelic goodness or leaving a situation to find a more heavenly existence. It's open to interpretation based on the context and the viewer's perspective.
It could mean they're ending a relationship or going on separate adventures.
It could be a story of friendship or love. Maybe the woman is helping the man or they are out enjoying a day together.
The story might involve the man having made a mistake and now he's running to avoid facing the consequences. Or perhaps he's on a quest and running away from obstacles in his path.
It might symbolize her leaving a situation or people behind. Maybe she's going on a new adventure or simply wants to be alone.
Maybe she just had a fight with her best friend and is feeling really sad about it.
It could symbolize a departure, maybe the end of a chapter or a change in situation.
The image of a man walking away in a cartoon might indicate a sense of isolation or independence. It could also imply that he's seeking something new or leaving behind what's no longer needed.
Maybe she's had an argument or is going to do something important elsewhere.
It could be that she's headed to a specific place or has a task to do. Maybe she's in a hurry and needs to go somewhere fast.