The significance of the inn in the Christmas story is multi - faceted. Firstly, it was a place that was supposed to provide shelter but couldn't for Mary and Joseph. This lack of accommodation led them to the stable, which became the birthplace of Jesus. It serves as a reminder of the simplicity and modesty of the Nativity. Moreover, it can be seen as a symbol of the world's initial rejection or lack of awareness of the great event that was about to occur. It's a crucial element in setting the scene for the miracle of Jesus' birth.