A possible plotline is that they go on a journey to discover more about their family's past. Along the way, they start to develop deeper feelings for each other than just sibling - like love. They struggle with this new - found emotion because of the taboo nature of it in the context of their family. Allison might use her power to try and make Luther forget about his doubts regarding their relationship, but then realizes that's not the right way. They then have to face the truth and figure out how to move forward while still being part of the family.
Perhaps a plotline where Allison and Luther are forced to work undercover in the normal world. They pretend to be a couple to blend in, which makes them realize how well they actually get along on a more personal level. As they face normal - world problems like getting a job and making friends, they also have to keep their powers a secret. This experience brings them closer together as they rely on each other in a completely different environment from the Umbrella Academy.
One interesting plotline could be Allison and Luther trying to reconnect after years of being apart due to the chaos in their lives. They might start by sharing memories of their childhood in the Academy that they had long forgotten. For example, they could recall a particular training session where they had to rely on each other to complete a difficult task. Another plotline could involve them facing a new threat together and having to use their unique abilities in harmony. Allison's power of rumor manipulation and Luther's super strength could combine in unexpected ways to defeat the enemy.