A possible plot could involve a curse or a prophecy. Naruto Uchiha has a strange mark on his body that is somehow connected to Mito Uzumaki's family. When they meet, there is an instant connection. They have to work together to figure out what the mark means and how it relates to their clans. During this process, they develop deep feelings for each other. Their love story could be filled with challenges as they face opposition from their respective clans who are against this unusual union.
I don't think it's a very common or popular concept. Naruto's story mainly focuses on his own journey and relationships within the context of his time. Mito Uzumaki was Hashirama's wife in the original story. Combining them in a love story in fanfiction is quite a stretch. It might appeal to those who like to break the boundaries of the original story and create unique, if not a bit out - there, love stories.
One idea could be a time - travel plot where Naruto somehow gets sent back in time and meets Mito Uzumaki. They initially have misunderstandings as Naruto's modern ways seem strange to Mito, but gradually they start to understand and fall in love. Another could be a story where Mito is in danger and Naruto, with his heroic nature, saves her and that becomes the start of their relationship.
One possible plot could be that Naruto, as Mito's brother, discovers some long - hidden family secrets. Maybe he finds out about a special power that has been passed down in the Uzumaki family but was lost over time. He then embarks on a journey to rediscover this power and use it to protect the village in a new way.
One possible plot could be Naruto discovering his connection to Mito Uzumaki early on. This could lead to him having an easier time controlling the Nine - Tails' chakra as Mito was also a Jinchuriki. He might inherit some of her unique sealing techniques and use them to protect the village in new ways.
One possible plot could be that Naruto time - travels and meets Mito Uzumaki. Mito could sense Naruto's strong chakra similar to Hashirama's. She might mistake him for a descendant of Hashirama at first. Then Naruto could learn about the origin of the Uzumaki clan from her and how they were powerful in sealing techniques. This encounter could also lead to Naruto getting some ancient knowledge about chakra control or sealing that he could use in his own time.
In a modern - day AU, Naruto might be a popular athlete and Mito could be a smart student. They meet at a school event. Naruto is immediately drawn to Mito's intelligence and Mito is attracted to Naruto's energy. Their relationship could start with simple conversations and then progress to going on dates, like to the movies or a sports event where Naruto is competing.
One possible plot could be that through the Edo Tensei jutsu, Mito Uzumaki is brought back to life. She teams up with Naruto. They could face off against an ancient enemy that once threatened the Uzumaki clan. Mito shares her old - world knowledge and skills with Naruto, and together they strive to protect the Hidden Leaf Village from this new threat.
She might encounter Naruto's hidden fears and help him face them. Maybe she'll discover memories Naruto has forgotten or suppressed.
One idea could be a time - travel fanfiction. Naruto Uchiha (assuming it's an AU where Naruto has Uchiha heritage) somehow travels back in time and meets Kushina Uzumaki. They could form an unexpected friendship as he tries to protect her from the events that would lead to her death. He could also use his knowledge of the future to change things in the village for the better.
I'm not sure specifically as there could be many different interpretations in fanfiction. It might be about Mito Uzumaki and some sort of fury - related situation in the Naruto universe, perhaps her showing great power or facing a difficult challenge.