One possibility could be that Sasuke is under a curse level 2 which affects his chakra flow. Sakura, being a skilled medical ninja, tries to find a cure. She has to face many challenges as the curse has some dark magic involved. Maybe she has to go on a journey to find rare herbs while also protecting Sasuke from those who want to use his cursed state for their own gain.
In this fanfiction, it could be that the 'curse' has given Sasuke some sort of power over Sakura. Sakura, being the strong - willed character she is, struggles against this new - found power dynamic. She may try to use her medical ninjutsu skills or her own chakra to counter the curse's effects while trying to free herself from Sasuke's grip, which might be strengthened by the curse.
Their relationship could develop as Sakura becomes more protective of Sasuke due to the curse. Sasuke, in his vulnerable state, starts to see Sakura in a new light. He realizes how much she truly cares for him.
One possible plot could be that Sasuke and Sakura, both being football fans, accidentally meet at a local football match. They start arguing about which team is better. But as the game progresses, they find themselves getting along and sharing their love for the sport. Eventually, they decide to form a small football club together with their friends in the village.
One possible plot could be that Sasuke gets injured during a mission and is brought to the hospital where Sakura works. Sakura then uses her medical skills to treat him, and during his recovery, they have deep conversations that rekindle their old feelings for each other.
Maybe Sasuke has been secretly planning the proposal for a long time. He starts by taking Sakura on a journey to different places they've been to in their past adventures. Along the way, he drops little hints. When they reach a beautiful, secluded spot by a waterfall, he gets down on one knee. He tells Sakura that she is the only one who has truly understood him and that he wants to spend the rest of his life with her. Sakura is shocked but then hugs him tightly and accepts.
Well, the plot could be that Sasuke has been away on a long mission. When he comes back, he sees Sakura has become very close to Naruto in a different way. Sasuke starts to feel this twinge of jealousy because he realizes he might have lost his chance with Sakura. He then has to decide whether to confront his feelings or keep them buried.
Perhaps Sakura kidnaps Sasuke because she suspects he is in danger from some unseen enemy. She believes that by taking him away from the normal routine, she can protect him. She might have some inside information about a threat to Sasuke's life. In the process, Sasuke at first is angry with her for this drastic measure, but then realizes her good intentions as she reveals what she knows.
One possible plot could be Sasuke finally fully integrating back into the village after his long travels. Sakura and he have a daughter. The story could focus on Sasuke trying to be a good father, like teaching his daughter some basic ninja skills. He also has to learn to be more open with his emotions, which Sakura helps him with.
Well, it could be about Naruto and Sakura finally having to face Sasuke who has gone too far in his pursuit of power. Maybe Sasuke is causing chaos in the village and they have no choice but to stop him.
A possible plot could be that they discover a new and dangerous jutsu that has been lost for centuries. They decide to train together to master it so that it can be used for the good of the village. Along the way, they learn more about each other's pasts and their friendship deepens.