Thane and Black Widow would be an interesting match. Thane is a deadly assassin with a code of honor in the Mass Effect universe. Black Widow is also an assassin with her own moral compass. They could exchange skills and stories about their past missions, and perhaps even work together to take down a common target in a stealthy manner.
Shepard and Captain America would be a great pairing. Both are leaders and have a strong sense of justice. Shepard could learn about Captain America's more old - fashioned values and leadership style from a different time, while Captain America could be impressed by Shepard's ability to lead in a diverse and technologically advanced universe.
Joker and Iron Man. Joker is the pilot of the Normandy and is very skilled at flying and handling advanced technology. Iron Man could relate to that and they could collaborate on improving the Normandy's systems or even building new ships together. Their banter would also be really fun to write as they are both witty characters.
Lara Croft and Commander Shepard would be an obvious and very interesting pairing. They are both strong leaders and adventurers. Lara's knowledge of ancient civilizations and her survival skills could complement Shepard's military leadership and combat experience in space battles. They could learn a great deal from each other.
Thane Krios and Darth Maul. Thane is a deadly assassin in the Mass Effect universe, and Darth Maul is a Sith assassin. It would be fascinating to see them in a battle of wits and skills. Thane's stealth and marksmanship against Darth Maul's lightsaber skills and Sith magic would make for an intense encounter.
Definitely Naruto and Hulk. Just imagine Naruto trying to calm down the Hulk when he's angry. It would be hilarious. And on a more serious note, Naruto's positive energy might have an effect on the Hulk. Also, Sakura and Captain America. Sakura is a strong - willed and powerful female character, and Captain America is a symbol of leadership and justice. They could bond over their shared values and exchange fighting strategies.
Sam Winchester and Bruce Banner would be an amazing pairing. Sam is highly intelligent and well - read, and Bruce is a brilliant scientist. They could bond over their knowledge and maybe even find a way to control the Hulk better. Also, Natasha Romanoff and Charlie Bradbury would be a cool pair. They're both strong, independent women with a lot of skills. Natasha could teach Charlie some combat moves, and Charlie could introduce Natasha to some cool geeky stuff like LARPing.
Another interesting pairing would be Captain America and Oliver Queen. Both are leaders with a strong sense of justice. They could have some great discussions about what it means to be a hero and how to lead a team. And when it comes to fighting, they could show off their different combat styles, with Cap's military - trained moves and Oliver's acrobatic and archery - based fighting.
Hawkeye and Sasuke would make a cool pairing. They are both very skilled in ranged combat. Hawkeye could learn some of Sasuke's Sharingan - enhanced archery skills, and Sasuke could be interested in Hawkeye's high - tech arrows. Also, Iron Man and Kakashi would be an interesting match. Iron Man's love for technology and Kakashi's use of Sharingan - based tech like his Ninja Hound summons could lead to some great interactions. They could even collaborate on creating new gadgets for both universes.
Deku and Shepard would be an interesting pairing. Deku is a young hero - in - training with a lot to learn, and Shepard is an experienced leader. Shepard could mentor Deku, and Deku could show Shepard the power of having a quirk. Their different backgrounds and skills would make for great character development.
I think Harry Potter and Captain America would make a great pairing. Harry has a strong sense of justice and leadership within the wizarding world, and Captain America has similar qualities in the superhero world. They could exchange ideas about leading their respective teams and learn from each other's experiences in fighting evil.
Definitely Harry Potter and Iron Man. Harry has his quick thinking and strong moral compass from growing up in the wizarding world, and Iron Man has his technological genius and sarcastic charm. They could bounce ideas off each other, with Harry explaining the intricacies of magic and Tony trying to find a scientific explanation for it. Maybe Tony could even create some gadgets to work with magic, like a device that can detect hidden magical objects.
Percy Jackson and Thor would be an interesting pairing. Percy has his water powers and connection to the sea, while Thor has his lightning powers. They could have some really cool battle scenes together, like when they face a water - and lightning - based enemy. Also, they both have a bit of a sense of humor and a heroic nature, so they'd probably get along well.