Hermione could also try to reason with Draco. She'll probably start a conversation, trying to understand his motives for capturing her. She might appeal to his better nature if she believes he has one, or try to make him see the error of his ways by using her logical arguments.
Hermione could become withdrawn. She might isolate herself from her friends for a while, spending her time in the library trying to make sense of it all. She might also feel a sense of betrayal, especially if they had some sort of understanding or relationship developing.
He could also be protective. Despite their differences, Draco might have some hidden feelings for Hermione. So, when he sees her scared, he might put aside their past enmity and try to comfort her or keep her safe from whatever is causing her fear. For instance, if there is a threat from another student or a magical creature, Draco could use his Slytherin cunning to protect her.
She might get angry and stand up for herself. Hermione is known for her strong will, so she could lash out at Draco verbally, using her intelligence to put him in his place.
She might initially be defiant. Hermione is a strong - willed character. So, she could start by giving Rowle a piece of her mind, showing that she's not afraid of him. She'd probably try to analyze the situation and figure out how she got captured in the first place.
She might be initially shocked. After all, she would have trusted her friends a great deal. Then she could become very sad and withdrawn. She might throw herself into her studies even more as a way to cope, trying to distract herself from the pain of losing her friends.
After the initial reactions, Hermione may choose to isolate herself for a while to figure things out. She would use this time to study and research, trying to find a solution to the problem with her friends. She might also look for new allies or resources within the fanfiction world to help her deal with the situation.
She might be initially shocked and hurt. Hermione is a character who values her friendships deeply, so their sudden departure would be a big blow. She could spend some time in denial, not believing that they would actually leave her.
Well, Draco could be very conflicted. On one hand, he has his own pride and his Slytherin upbringing which might tell him to stay away. But if he has developed deeper feelings for Hermione in the fanfic, he might put aside their past differences. He could start by using his family's resources to find a cure or at least better treatments for her cancer. He may also become more protective of her, keeping her away from those who might be unkind about her illness.
She might initially be defensive. Hermione is proud of her intelligence and actions, so she could start by trying to justify what she did. For example, she could say that she was only trying to help or that she had good intentions.
She might be initially shocked. After all, Draco is usually seen as this tough Slytherin. But then she could feel sympathy. For instance, she might offer him a handkerchief without saying much at first.