She might get angry and stand up for herself. Hermione is known for her strong will, so she could lash out at Draco verbally, using her intelligence to put him in his place.
Hermione could also become more withdrawn. She might isolate herself in the library even more, focusing on her studies as a way to cope with the emotional pain. And she might start to avoid Draco at all costs, changing her usual routes in Hogwarts to not cross paths with him.
Hermione could become withdrawn. She might isolate herself from her friends for a while, spending her time in the library trying to make sense of it all. She might also feel a sense of betrayal, especially if they had some sort of understanding or relationship developing.
Well, Draco could be very conflicted. On one hand, he has his own pride and his Slytherin upbringing which might tell him to stay away. But if he has developed deeper feelings for Hermione in the fanfic, he might put aside their past differences. He could start by using his family's resources to find a cure or at least better treatments for her cancer. He may also become more protective of her, keeping her away from those who might be unkind about her illness.
She might be initially shocked. After all, Draco is usually seen as this tough Slytherin. But then she could feel sympathy. For instance, she might offer him a handkerchief without saying much at first.
She might be heartbroken at first. Hermione is someone who invests deeply in her relationships. She would likely retreat into her studies as a way to cope, burying herself in books to try and forget the pain.
At first, Hermione would be shocked. But then, she would quickly compose herself. She could play along with Draco and Blaise for a while, pretending to be compliant while she actually gathers information about their motives and the place where they are holding her. She might also try to turn them against each other by highlighting their differences in goals or personalities. Given her intelligence, she would surely come up with a clever plan to get out of the situation.
Hermione might be shocked at first. She has always seen Draco as an adversary, so a neck kiss from him would be completely unexpected. She could push him away immediately and demand an explanation.
Hermione could also be more understanding in some fanfictions. If she senses that there's something deeper behind Draco's actions, she might try to calm the situation down. She could ask him why he did it instead of immediately retaliating. Maybe she sees a glimmer of vulnerability in his eyes and decides to approach the situation in a more empathetic way. This could then lead to a conversation that changes their relationship for the better.
Hermione might initially be shocked and afraid, but she would quickly gather her wits. She would assess Draco, trying to figure out if there was any way to sway him to her side. Given her ability to see the good in people, she might try to appeal to any sense of morality Draco has left, all while secretly planning her escape or a way to undermine Voldemort's plan of using her as a pawn against the good side.
Hermione might initially be furious. She is a strong - willed character, so being tied up against her will would surely make her angry. She would probably start using her wits right away, trying to figure out a way to free herself, whether it's through magic or by tricking Draco.
One possible reason could be his Slytherin pride and the long - standing rivalry between Gryffindor and Slytherin. He might have said something mean to Hermione in the heat of that rivalry. Another reason could be jealousy. Maybe Hermione is achieving more academically or getting more recognition, and Draco, being a proud pure - blood, can't stand it.