In the fanfiction, Itachi might be acting according to some secret mission that endangers Sakura's life. Sasuke, who has a strong bond with Sakura now, won't let that happen. He jumps in and uses his ninja skills. Sasuke could have developed some new jutsu that he uses to counter Itachi's attacks. This not only saves Sakura but also shows Sasuke's growth as a ninja. And Sakura, in turn, might be in the middle of researching some important medical ninja stuff that Itachi's actions could have disrupted if not for Sasuke.
In this kind of fanfiction, perhaps Itachi uses his quick reflexes and ninja skills to catch Sakura as she's about to fall. Maybe she was in a dangerous situation like on a crumbling cliff or a collapsing building. Itachi, being the powerful ninja he is, swoops in just in time to prevent her from getting hurt.
One possible plot twist could be that Sasuke has been under a genjutsu that makes him target Sakura, and Naruto has to break the genjutsu first to truly save her. Maybe the one who cast the genjutsu is a new, powerful enemy who wants to disrupt the bond between Team 7. Naruto, with his strong will and newfound powers, manages to find the source of the genjutsu and free Sasuke from its control, thus saving Sakura from harm.
Sasuke's character could develop in terms of his loyalty. By saving Sakura from Itachi, he shows his loyalty to his friends and comrades. He is no longer just the revenge - driven Sasuke. He has grown to care about others' safety.
The plot could be that Sakura has been drugged by some enemy ninjas. The drug makes her lose control and she attacks Naruto. Sasuke, being observant, realizes what's going on. He quickly uses his genjutsu to put Sakura to sleep before she can harm Naruto. Then he and Naruto work together to find the antidote for Sakura.
In this kind of fanfiction, Itachi might use his powerful Sharingan abilities. He could perhaps create illusions to mislead Orochimaru and his minions, then quickly snatch Sasuke away. For example, he could make Orochimaru think that Sasuke is in a completely different location while he secretly approaches and rescues him.
Well, in such a fanfiction, perhaps Sakura is in a very dark place mentally, feeling hopeless and considering suicide. Itachi, with his perceptive nature, might notice her distress. He could use his skills and wisdom to talk her out of it, maybe by sharing his own experiences of dealing with difficult situations in the ninja world. He would offer her hope and a new perspective on life, making her realize that there are always reasons to keep living.
In many Sasuke - Sakura - Gaara fanfictions, Sasuke saving Sakura from Gaara can be a really exciting plot. It often shows Sasuke's strength and his hidden feelings for Sakura. Maybe he uses his Sharingan to outwit Gaara's sand attacks and rescue Sakura just in time.
One possible plot is that Naruto uses his ninja skills in a creative way. For example, he could use the Transformation Jutsu to transform into someone the fangirls would be more interested in, like a famous singer or actor in their world. While the fangirls are distracted by this new 'celebrity', Naruto grabs Sasuke and they make their escape. Another aspect could be that Sasuke is initially reluctant to be 'saved' by Naruto because he doesn't want to seem weak. But as the situation gets more out of hand, he realizes he needs Naruto's help. The two then have a heart - to - heart conversation after escaping the fangirls about how Sasuke feels about his new - found 'fame' among the fangirls.
One common theme is redemption. Itachi is often seen as a tragic figure in need of saving, and Sakura becomes the instrument of his redemption. Another theme is the power of friendship or love. Sakura's actions are usually driven by her feelings for Itachi, whether it's a deep friendship or something more romantic.
Perhaps in the fanfiction, Sakura and Itachi are in a police force that has to deal with international ninja disputes. Sakura, with her intelligence and strong will, and Itachi, with his strategic mind, work together to prevent a full - scale war between two large ninja clans. They face many challenges along the way, including distrust from their own comrades who are skeptical of their unorthodox methods.