Some of the more powerful and vengeful spirits in Tartarus could be the main antagonists. These spirits could possess demigods or mortals close to Percy to get to him. They might be angry that he escaped their domain and want to drag him back. Additionally, there could be a group of rogue demigods who believe that Percy has been corrupted by Tartarus and they see it as their duty to stop him, even if it means becoming his enemies.
The Titans or Giants that were banished to Tartarus could be the main antagonists. They might see Percy as a threat or an opportunity to escape and seek revenge on the Olympians.
Maybe it's the Titans who are still lurking in Tartarus and don't want Percy and Zoe to succeed in whatever mission they have. The Titans could see them as a threat to their potential future plans of rising again.
The Titans that were banished to Tartarus could be major antagonists. They might see Percy as an intruder and a threat, and try to stop him from escaping or even try to use him for their own purposes. Also, the various monstrous creatures native to Tartarus, like the Empousai or the Arai, could constantly be attacking Percy.
There could also be a group of demigods who are jealous of Percy's power due to his unique parentage. They might form an alliance against him, trying to steal his powers or at least make his life difficult. They could be led by a demigod who has a grudge against Percy or is power - hungry.
In the fanfiction, the environment of Tartarus itself could be considered an antagonist. The extreme heat, the toxic gases, and the ever - present danger of falling into bottomless pits. And on top of that, there could be some sort of demon - like creatures that are specifically created or summoned to hunt down Percy and Zoe and prevent them from achieving their goals.
One possible plotline could be Percy having nightmares about his time in Tartarus. He might struggle with PTSD, which could affect his relationships with his friends and family at Camp Half - Blood. Another could be that he brings back some sort of dark power or knowledge from Tartarus that he has to figure out how to control or use for good. Maybe he discovers a way to close the entrance to Tartarus permanently so that no more monsters can come out and endanger the demigod world.
The monsters native to Tartarus could also be antagonists. These could be huge, grotesque creatures that have never seen the outside world. They might attack Percy on sight, seeing him as prey. Some of them could be powerful enough to even give Percy a hard time, especially if his powers are weakened in Tartarus.
Perhaps he could make an alliance with some of the less hostile creatures in Tartarus. There might be beings who are also tired of the chaos and want to help Percy in exchange for something, like a promise to free them from Tartarus if he ever gets the chance. Percy is known for his charisma and ability to make friends, even in the most unlikely situations.
In some more creative fanfictions, new characters might be introduced. For example, a powerful demigod who was born in Tartarus and has unique abilities. These new characters can add a fresh twist to the story, interacting with Percy and the others in unexpected ways, and often bringing new plotlines related to the mysteries of Tartarus.
The main antagonist could be Nyx. She is a powerful primordial goddess of the night, and Tartarus is her domain in a way. She might see Percy as an intruder and try to stop him from escaping or achieving his goals there.