It could be an inmate with a personal vendetta against Naruto. Maybe this inmate has a connection to one of Naruto's past enemies or has a grudge because of Naruto's fame. This inmate then uses the chaos and danger of the Blood Prison to carry out his revenge and is the main reason for Naruto's death.
The warden of the Blood Prison could be the main antagonist. He might be a power - hungry and corrupt individual who sees Naruto as a threat to his control over the prison. So, he devises plans to get rid of Naruto, which ultimately lead to Naruto's death.
It could be the warden of the Blood Prison. He might be a corrupt figure who is using the prison for his own gain. He sees Naruto as a threat to his operations and tries to keep him locked up at all costs.
It could be one of the powerful and corrupt prison guards. They might have their own hidden agendas and see Naruto as a threat to their power or secrets within the Blood Prison. So, they start a scheme to make it seem like Naruto has betrayed everyone.
Might be one of the powerful guards who has a grudge against Naruto for some reason. Maybe he believes Naruto is a threat to the order in the prison and tries to get rid of him secretly.
It could be a corrupt ninja from within the village who wants Naruto out of the way. Maybe someone jealous of Naruto's popularity and power, so they frame him and get him sent to prison. This antagonist would then try to keep Naruto in prison by any means necessary.
It could be a new character created just for the fanfiction. Maybe a rogue ninja who has mastered a dark and powerful jutsu that Naruto has no defense against. This antagonist could be seeking revenge on Konoha for some past wrong and sees Naruto as the biggest threat to his plans.
It could be someone who was secretly behind Naruto's death in the first place. Maybe a rogue ninja who has a vendetta against the Hidden Leaf and saw Naruto as a major obstacle.
It could be an ancient evil that was sealed away long ago but has been released due to Naruto's death. Maybe Naruto's sacrifice in his previous life weakened the seal, and now this evil has emerged. It could be a powerful demon or a dark ninja with extremely strong and malevolent jutsu.
It could be Orochimaru. Since Naruto was a potential threat to his plans in the original story, if Naruto died as a baby, Orochimaru might be able to carry out his experiments and schemes more freely without having to worry about Naruto interfering in the future.
It could be an unknown shinobi from a far - off land. A shinobi with powers that Naruto has never encountered before. This new antagonist might have some dark and powerful jutsu that Naruto simply isn't prepared for, which ultimately leads to his downfall on the bridge.
A rogue ninja from another village could be the main antagonist. Maybe a ninja from the Hidden Mist Village who has a personal grudge against Konoha and sees Naruto as the symbol of Konoha's strength. So, he devises a complex plan to take down Naruto. This ninja could have some unique and deadly jutsu that Naruto has never faced before, which ultimately leads to his downfall.