A young girl who has a special gift of understanding Pokémon and Mewtwo could be the main characters. The girl stumbles upon Mewtwo in a forest and tries to help it deal with its inner turmoil. Their relationship develops as they share their experiences and emotions.
A battle - hardened trainer and Mewtwo could also be the main characters. The trainer, who has seen a lot in the Pokémon battles, meets Mewtwo. They initially clash but then find common ground as they both strive for power in different ways. Eventually, they form an unexpected partnership.
The main characters could be a Pokémon researcher and Mewtwo. The researcher is fascinated by Mewtwo's creation and wants to study it further. Mewtwo, at first, is suspicious but gradually warms up to the researcher as they spend more time together.
The relationship might develop through a shared goal. Say there is a powerful and evil Pokémon that is threatening both humans and Pokémon. The human and Mewtwo realize they need each other's help. As they work together to defeat this common enemy, they learn about each other's strengths and weaknesses. The human might be good at strategizing, while Mewtwo has the raw power. Through this cooperation, their relationship could grow from mere allies to close friends.
Ash could be one. He has a way of befriending all kinds of Pokémon, and his encounter with a friendly Mewtwo would be an exciting story. He could learn a lot from Mewtwo's psychic powers and wisdom.
The main characters could be a tall girl who is a dancer and a human who is a choreographer. The choreographer is impressed by the tall girl's unique presence on the dance floor and they start working together, which leads to a deeper connection.
Obviously, the bubble - head nurse and the human are the main characters. The bubble - head nurse might be a kind - hearted and unique individual with her own set of quirks and abilities related to her appearance. The human could be someone ordinary at first but then becomes extraordinary through their interaction with the nurse.
Obviously, Peg from Goof Troop would be one of the main characters. For the human character, it could be a young, adventurous boy named Tom. Tom is always curious about the forest where Peg and the Goof Troop live, and his eagerness to explore leads him to cross paths with Peg.
Obviously, Ash is one of the main characters. He is the Pokémon trainer on a quest to catch Mewtwo.
One idea could be that a human scientist is working on a project related to Mewtwo's powers. They start to communicate on a deeper level, and Mewtwo begins to see the human as an ally rather than an enemy. The human, in turn, tries to understand Mewtwo's complex emotions.
Obviously, the two Mewtwos are the main characters. They are the ones whose encounter drives the story forward.
A new human character could be introduced, like a military leader who is leading the invasion. He could have his own motives for wanting to take over the Soul Society, such as a thirst for power or a belief that humans should control all realms.
The plot could be about Mewtwo trying to control Missingno's glitch powers.