There could be a new, made - up character. A digital wizard of sorts who has learned how to cross over from the popularmmos world to the Percy Jackson world. He wants to control all magic and technology, believing that by merging the two worlds under his rule, he can become the most powerful being. So he sets out to stop anyone who stands in his way, including Percy and the popularmmos crew.
A great antagonist could be a rogue demigod who has been corrupted by power. This demigod could have discovered a way to combine the darkest parts of Greek and Roman magic and is using it to cause chaos among both camps. He or she might see Jason and Percy as the biggest threats to their plans and target them specifically.
Well, maybe the popularmmos characters accidentally stumble into Camp Half - Blood. Percy and his friends are initially suspicious but then realize they can use the unique skills of the popularmmos crew. Together, they embark on a quest to retrieve a magical item that has been stolen and is now hidden in a strange digital - mythological hybrid realm.
It could be an ancient sea creature that was once imprisoned by Amphitrite and Poseidon. Now that Percy has come into the picture, it senses an opportunity to break free. It uses its dark powers to manipulate the ocean and turn it against Percy and Amphitrite, hoping to create enough chaos to shatter the chains that bind it once again.
It could be a new monster that is specifically targeting Percy's mortal connections, like Paul. Maybe a monster that feeds on the fear of mortals who are close to demigods.
Maybe a group of mercenaries who are also interested in the valuable artifacts related to Greek mythology. They would be willing to do anything to get their hands on them, and they are a threat not only because of their weapons but also because they have some knowledge of the ancient secrets that could be used against Percy and Lara. They could set up ambushes and try to steal the artifacts from Percy and Lara while they are in the middle of their exploration.
It could be a power - hungry Atlantean noble who wants to rule not just Atlantis but also the surface world. He sees Percy as a threat to his plans and tries to stop him at every turn.
A new and powerful demon that has emerged from the darkest corners of the underworld. This demon is bent on using Percy's connection to the overworld to break through the barriers between the two worlds and unleash chaos. It has powers that are different from what Percy has faced before, like the ability to manipulate the very essence of the underworld's environment.
A powerful Amazonian sorceress who has turned against her own kind and is now trying to use dark magic to take over the world. She could see Percy as an obstacle in her path and constantly try to defeat him.
Maybe it could be a demigod who has become obsessed with power through gaming. This demigod, let's say a child of Hades, discovers a way to use dark magic and combine it with gaming technology to try and rule over all the other demigods. He sees Percy as a major threat to his plans because Percy is so popular and has strong powers, so he constantly tries to undermine Percy at every turn.
The goddess Hera might also be a great antagonist. Since she has a history of interfering in the lives of demigods, she could be jealous or threatened by Percy's rebirth. She might try to stop him from reaching his full potential in his new life or cause trouble between him and his new allies.