It could also be that Sakura has found out something about Sasuke that she doesn't like. For example, if he has been involved in some dangerous or unethical activities. As a person with strong moral values, she would then want to distance herself from him to avoid getting involved in any trouble or because she is disappointed in his actions.
One possible reason could be that Sakura has grown tired of Sasuke's cold and distant attitude. In many Naruto storylines, Sasuke is often preoccupied with his own goals and doesn't show much warmth towards Sakura. So, in the fanfic, she might have finally reached her limit and told him to get away.
Maybe Sakura has realized that her feelings for Sasuke were more of an infatuation and not true love. She could have had a moment of self - discovery and decided that she needs space from him to figure out her own life and what she really wants. In this case, asking him to get away is a step towards her own personal growth.
Perhaps she is being chased by some unknown enemies in Konoha who are after her for some reason. She might think that running away from Konoha is the only way to protect herself and those she cares about. It could also be that she has a new mission or purpose that she believes can only be achieved outside of Konoha, and she is willing to sacrifice her life in the village for it.
Well, one reason could be Sasuke's continued obsession with his revenge. He might be so focused on it that he ignores Sakura's feelings and concerns, which could lead to a fight. For example, if Sakura tries to persuade him to let go of his revenge and he refuses, it could spark an argument.
One possible reason could be Sasuke's continuous absence due to his solo missions. He's always away, leaving Sakura feeling lonely and neglected in their relationship. This lack of emotional and physical presence can gradually erode the bond between them.
Sasuke might believe that he's a danger to Sakura. Given his associations with dangerous elements and his own dark powers, he may feel that getting close to Sakura would put her in harm's way. Therefore, he rejects her to protect her. This is a common theme in many fanfics where Sasuke is portrayed as having a strong sense of self - sacrifice when it comes to Sakura.
One possible reason could be that Sakura has finally grown tired of Sasuke's aloof and cold behavior towards her. She might have realized that she has been constantly chasing after him while getting little in return, so she decides to ignore him as a form of self - preservation.
One reason could be that Sasuke really values Sakura's friendship and is afraid of losing it to someone else. Maybe she sees others getting closer to Sakura and feels left out.
One possible reason could be Sasuke's continued absence. He's often away on missions, leaving Sakura feeling lonely and neglected. In the story, this could build up over time until she decides she can't take it anymore and argues for divorce.
In the fanfic, it could be that Sasuke doesn't appreciate Sakura enough. She might pour out her love and support for him, but he doesn't return it in the way she hoped. Sakura may have expected a more reciprocal relationship where her feelings are acknowledged and valued. Since that's not the case, she starts to regret her choice of Sasuke.
In the fanfic, it might be because of a misunderstanding. For example, Sasuke could be wrongly accused of something, and Sakura, believing the false rumors, is so disappointed in him that she refuses to talk. Or perhaps Sasuke accidentally said something really offensive during an argument, which made Sakura so angry that she just cut off communication.
One possible reason could be extreme emotional distress. Maybe she feels like she has failed Sasuke in some way, like not being able to save him from the darkness, and she self - harms as a form of punishment. Another reason could be in a situation where she has to make a sacrifice. For example, if Sasuke is in danger and her cutting off her arm is the only way to activate a certain power or jutsu to save him.