At first, Naruto would likely be very confused and hurt. He has always craved family love and acceptance, so this sudden turn would be a huge blow. He might try to plead with his family, asking them to believe him and give him a chance to explain.
His friends would be shocked at first. Sasuke, for example, might see it as a sign of weakness on Naruto's part, that he let Minato do this to him. Sakura would be worried about Naruto's well - being and would try to find a way to reverse the process. Shikamaru would be thinking about the long - term consequences for the village and for Naruto's relationships. Overall, they would be very concerned and try to get Naruto back to his normal self.
Hinata's family would also have to deal with the emotional aspect. They love Hinata in her normal state, and now they have to adjust to this new form. They might start to remember when Hinata was actually a baby before and all the hopes and dreams they had for her then. Some of the more conservative members of the family might be more hesitant to let Naruto be around her, but the more open - minded ones could see that Naruto's presence is actually good for her in this state. And they would all be united in their goal to get Hinata back to her normal self.
His family would be extremely worried. Hinata, as his wife, would probably be in a state of panic. She might start searching everywhere for him, using all her skills and resources. His children would be confused and sad, constantly asking where their father is. And the rest of his family, like his friends who are like family, would also be on high alert and start looking for him right away.
At first, Naruto would likely be extremely shocked. He has always considered Sakura a friend and teammate, so this would be a huge blow. He might question his own judgment in trusting her.
Sakura might be initially shocked. But being a good friend, she would quickly try to understand what happened to Naruto. She could offer to help him find a way to change back or support him in dealing with the new form. Sasuke, on the other hand, might be more aloof at first. He would see Naruto's transformation as a sign of weakness, but as time passes and Naruto proves his strength in the new form, Sasuke might start to respect him again.
Well, Naruto's friends' reactions would depend on their personalities. Sasuke, if he's around, might seem indifferent on the surface but secretly think that Naruto is being an idiot as usual. Hinata might be a bit shy about the whole situation, but also happy for Naruto if she senses that he really likes Temari. And Lee would probably be super excited and start shouting words of encouragement to Naruto, saying things like 'Go for it, Naruto! Show your youthfulness in this pursuit of love!'
At first, Naruto would probably be extremely confused and hurt. He loves his mother and can't understand why she would do such a thing. He might try to find her immediately to talk it out.
If Orochimaru were to turn Naruto into a girl in a fanfic, Naruto's personality could change in several ways. His boldness might be tempered a bit as he adjusts to his new form. He might become more cautious in some situations because he's now in a more vulnerable - looking body. However, his core values of loyalty and friendship would remain the same. He might also develop a new sense of femininity, which could add a new aspect to his personality. For example, he could be more nurturing towards his friends, something that was perhaps less emphasized when he was male.
The Naruto fandom would likely be very divided. Some fans would be extremely outraged as it goes against the core values and character of Naruto. They might condemn such a fanfiction.
In some fanfics, it could be related to a prophecy. His family might believe that Naruto is going to bring about a great disaster according to a misinterpreted prophecy. So, they turn on him in an attempt to prevent the prophecy from coming true, even though they are wrong in their understanding.