His relationship with Sasuke would likely be very different. Sasuke might initially be shocked and confused. They would have to re - evaluate their friendship in a new light, with Naruto now in a female form.
In terms of relationships, Naruto's transformation into a vampire would have a huge impact. His friends in Team 7 would be thrown into confusion. Sakura might try to find a way to 'cure' him at first, which could strain their relationship. Sasuke might see Naruto's new state as a sign of weakness or an opportunity to gain power. Naruto's relationship with the Hokage, whether it's Tsunade or someone else, would also change. The Hokage would have to decide how to handle a vampire - ninja in the village, whether to keep it a secret or make it public. And Naruto would have to deal with the emotional turmoil of potentially losing the trust and closeness of those he cares about.
One possible reason could be for a mission. Maybe the mission requires infiltrating a female - only place or getting close to a female - only group, so Naruto decides to turn himself female to better complete the task.
His relationship with Sasuke would likely become more of a partnership. As Hokage, Naruto would need Sasuke's skills and knowledge to protect the village. They would probably have regular meetings to discuss security and other important matters.
If Naruto could turn invisible in the fanfic, his relationships would experience a great deal of upheaval. His peers in the village might start to view him as more of an enigma. Some might be in awe of his power, while others could be a bit intimidated. His relationship with the older generation, such as the village elders, could become more complex. They might see him as a greater asset but also a potential threat if his power gets out of control. His relationship with Hinata could also take an interesting turn. Hinata might be shy as always but also more curious about Naruto's new ability, and Naruto could use his invisibility to playfully interact with her in a new way.
His relationship with Sasuke could be different. Maybe Sasuke would be in awe of Naruto's new powers at first. They might have less of a rivalry and more of a partnership from the start, with Sasuke seeing Naruto as a step ahead in power and knowledge.
In terms of his romantic relationships, if there were any potential love interests, they might be more hesitant. However, Naruto's determination and positive attitude could still win them over. His relationships with his teammates from Team 7 would likely shift. They would need to adjust their battle strategies to account for his one - eyed state. His bond with Hinata could also be tested as she might worry more about his safety and his ability to protect himself and the village.
His relationship with his friends would be strained. For example, Sasuke might notice a change in Naruto's attitude towards him and others. Naruto may start to avoid his friends as he no longer trusts them like he used to.
His relationship with Sakura would be very different. Instead of the one - sided love she had for Sasuke, she might be both attracted and repelled by Naruto's new anti - hero persona. She could see the good in his intentions but be horrified by his methods.
Naruto's relationship with his sensei, like Kakashi, would also change. Kakashi would be extremely vigilant and try to train Naruto to control the Sephiroth - like powers. He might also be researching about this strange phenomenon. As for his friends in the village, some might be afraid of him, while others might see it as an opportunity for the village to become stronger. But overall, Naruto would feel a bit isolated as he's different now.
His relationships would change a great deal. He'd probably form a father - son type of bond with the Raikage. With the other Cloud ninjas, he'd start as an outsider but gradually earn their respect through his skills and determination. His relationship with his friends in Konoha might become more complex as he now has a new allegiance to the Hidden Cloud.