We could also consider creating a new antagonist specifically for the crossover. This could be a powerful being that combines the elements of both the OPM world and Saitama's world. For example, a creature with the regenerative abilities of some OPM monsters and the intelligence and strategic thinking of a powerful villain from Saitama's world.
Garou from OPM might also work well. His ideology of being a 'human monster' and his constantly evolving strength could make him a formidable foe for Saitama. Their clash could be not only about physical strength but also about their different views on what it means to be a hero or a monster.
Another interesting concept is a crossover where the villains from the OPM world are a threat to Saitama's own world. Saitama then has to team up with the OPM heroes to fight back. This could lead to some really cool fight scenes and interactions between different characters.
If it's a crossover with Alice in Wonderland, the Queen of Hearts could be the main antagonist. The Queen might see Tinkerbell as an intruder and try to behead her. Tinkerbell would have to use her wits and magic to survive in the crazy world ruled by the Queen of Hearts.
A powerful demon from another dimension could be the main antagonist. This demon could be attracted to the power that Sinbad wields in the Magi world and wants to steal it for himself. He could start causing chaos in both the world Sinbad is from and the world he's been transported to in the crossover.
A new character could be introduced as the main antagonist. For example, a being from another dimension who has been observing both Sonic's and Megaman's worlds. This being realizes that by combining the chaos energy from Sonic's world and the advanced robotics technology from Megaman's world, it can create a new, all - powerful empire. So it starts to manipulate events in both worlds to bring about this combination, while Sonic and Megaman have to stop it.
Dr. Eggman and Dr. Wily could team up. Dr. Eggman has his mechanical creations and knowledge of Sonic's world, while Dr. Wily is an expert in creating powerful robots in Mega Man's world. Together, they could be a formidable force against Sonic and Mega Man.
Thanos could be an interesting antagonist in a crossover. Imagine Dr Fate having to use his magic to try and stop Thanos from getting all the Infinity Stones. Thanos' brute force and determination would be a great contrast to Dr Fate's magical finesse.
An alien entity that has been dormant beneath Smallville for centuries could awaken. This entity could view Chloe and Clark as threats to its plans of taking over the town and the world. It could use its advanced powers to manipulate the townspeople and turn them against Chloe and Clark, making it a formidable foe.
Perhaps an ancient evil that has been sealed away in the empire for centuries but is released due to the chaos of the crossover. This entity could be more powerful than any foe the Naruto characters have faced before, forcing them to find new ways to fight.
A group of rogue shinobi and some of Daria's school bullies could team up. The shinobi would give the bullies some ninja powers, and together they would cause trouble in both worlds. This group would be difficult to deal with as they combine the physical strength of the shinobi with the local knowledge of the bullies.
It could be a lemon - loving pirate who has a grudge against Luffy for some reason. Maybe Luffy accidentally destroyed his precious lemon grove on an island. So this pirate, with his crew of lemon - themed fighters, constantly tries to sabotage Luffy's adventures and steal his treasures.