At the start, Ash might underestimate Hunter J's yandere nature. He'd think he could just handle her like any other enemy. But as she starts to show her obsessive side, like targeting his Pikachu specifically or trying to isolate him from his friends, Ash would become more cautious. He would start to analyze her motives and actions more carefully. He might even try to find out if there's a way to cure her of her yandere tendencies, but if that's not possible, he'd be ready to battle her with all his might. His love for his Pokémon and his friends would fuel his determination to stand up to her.
One possible plot could be that Hunter J targets Ash for some unknown reason. Maybe she sees his unique bond with his Pokémon as a threat or something she wants to possess. Ash, being his usual brave self, has to outwit her while also protecting his Pokémon friends from her devious plans.
Naruto might be initially confused. He's used to people being friendly or at least straightforward with their intentions. So when Mikoto starts showing her yandere side, like getting overly possessive, Naruto would probably be like 'What's going on?'. He could try to talk to her and understand her behavior at first.
Naruto would probably be really confused at first. He's used to a loving mother figure, not a yandere one. He might try to talk to her and understand why she's acting so strangely.
Naruto might be really confused at first. He's used to people being friendly or having normal crushes, but a yandere is a whole different level. He'd probably try to talk to her and understand why she's acting so strangely.
Ash would likely be shocked at first. He's so used to seeing the good in people, especially fellow trainers. But then he'd probably get angry and determined to set things right. He has a strong sense of justice, so he wouldn't let the betrayal go unpunished.
At first, Naruto might be really confused. He's used to the normal Sakura, so when she starts acting all yandere, he'd be like 'What's going on, Sakura - chan?'. He'd probably try to talk to her and find out what's wrong.
Naruto might be initially confused. He's used to people being friendly, but Yandere Ino's possessiveness would be new to him. He could try to talk to her to understand what's wrong. But if she gets too extreme, he would probably be a bit scared and try to distance himself.
If the female clone's actions become more extreme, Naruto would likely become more serious. He has a strong sense of justice and protecting his friends. He wouldn't let her harm anyone. He might try to use his own ninja skills to subdue her and figure out a way to reverse whatever made her this way. He'd also draw on his own experiences of being an outcast and try to reach out to her on an emotional level, hoping to change her yandere ways.
Ash would probably be initially shocked. He is used to seeing the good in people and would not expect such a betrayal from Cynthia. He might stand there in disbelief for a moment, unable to process what has just happened.
I think Ash would be angry as well as hurt. He's a passionate trainer and his friends mean a great deal to him. He might challenge May in a Pokémon battle, not to defeat her but to make her see how wrong her betrayal is. And during the battle, he would keep asking her to come back to their old friendship.