His relationship with Toothless would be very different. Toothless might be initially confused and a bit hesitant around Hiccup in his new form. But as time passes, they would develop a new kind of bond based on Hiccup having to adapt to being a dragon. With Astrid, it could be strange at first. Astrid might be both curious and a bit jealous of Hiccup's new dragon form. She would have to see Hiccup in a whole new light.
With his human friends, it would be really tough. They might be scared of him at first. Astrid, for example, would be conflicted. She was attracted to Hiccup as a human, but now he's a dragon. She would have to overcome her fear and try to find a way to communicate with him. And Hiccup would feel isolated from his human friends, longing for the connection they once had.
His relationship with Toothless would be very different. Toothless might be more protective of him in his new form, as if sensing that Hiccup is more vulnerable as a female Night Fury. And Hiccup would have to communicate with Toothless in new ways, perhaps using more body language that is typical of female Night Furies.
His relationship with Astrid might become more complicated. She might be initially shocked or even a bit scared of his half - dragon side. But as she gets to know that it doesn't change who Hiccup really is, they could grow closer. His dragon friends, on the other hand, might see him as more of an equal now that he has a dragon part in him.
His relationship with Toothless would change drastically. Instead of being the rider, he becomes like a little sibling or a young apprentice to Toothless. Toothless would have to be more protective and patient with Hiccup.
If Eragon turns into a dragon, his relationship with Saphira would be very different. They might become equals rather than dragon and rider. His human friends may be initially scared or confused. But some, like Arya, might see it as an opportunity to gain a powerful ally for the fight against evil. His enemies would be more fearful of him, seeing him as a greater threat.
It can strengthen his bond with Toothless even more. Since they already have a deep connection, the dragon blood could make them almost telepathic. They would understand each other without even having to speak or make gestures.
Hiccup's relationship with his father (if his father is still alive in the fanfiction) would be complex. His father might be proud of him for achieving such a powerful status, but also worried about how the other tribes would react. Hiccup would also have a different relationship with the dragons in general. He would no longer be just a friend to them, but a leader, a dragon god. This could lead to some dragons being more submissive to him, while others might test his new authority.
In a fanfiction where Issei turns into a dragon, his relationships would be in flux. His relationship with his mentors or those he looks up to might change as they now see him as a different kind of being. They might treat him with more caution or more respect depending on how they view dragons. His friendships with his peers would also be altered. Some might see him as a weapon to be used in their battles or struggles, while others would see him as a friend in need of support. Romantically, if he had feelings for someone, that person would have to deal with the fact that Issei is no longer fully human. There could be jealousy from others who might want to be with the powerful dragon - Issei, or there could be newfound admiration from those who previously overlooked him.
His relationship with his uncle Iroh would be deeply affected. Iroh has always been a guiding figure for Zuko. If Zuko turns into a dragon, Iroh would be worried but also proud in a way. He would search for ways to help Zuko, and their relationship would become more about Iroh protecting and guiding Zuko in this new and strange form. Zuko, in turn, would rely more on his uncle's wisdom during this time.
One possible fanfic could be that Hiccup's transformation into a Dragon Toothcup is the result of a magical experiment gone wrong. Maybe a wizard in Berk was trying to create a new form of dragon - human bond and accidentally merged Hiccup with a special dragon toothcup. As a Dragon Toothcup, Hiccup could have unique abilities like being able to sense the emotions of dragons more acutely and communicate with them on a deeper level. His friends would be both shocked and intrigued, and they would have to figure out how to reverse the transformation.