Her relationship with her family could also be different. Her parents might treat her more delicately or have different expectations. And her siblings might tease her in new ways or be more protective. Also, her relationship with her enemies could change as they might underestimate her or be more hesitant to fight a girl.
Well, consider her relationship with the Soul Reapers in the Soul Society. As a girl, she might be treated differently by the male Soul Reapers. Some might be more chivalrous towards her, while others might be jealous or resentful. Captain Hitsugaya, for example, could have a different kind of respect for her. And her relationship with the female Soul Reapers could be a mix of camaraderie and competition. They might be more willing to include her in certain female - only traditions or events in the Soul Society, which would change the overall social fabric of her relationships there.
If Draco becomes a girl, his relationship with his Slytherin friends would likely change. Some might be more protective of her, while others could be jealous of the attention she gets. His relationship with Harry Potter would also be different. Instead of the typical rivalry, there could be a more complex dynamic, perhaps even a begrudging friendship as they both realize they have more in common than they thought. And with his family, his father might have a hard time accepting the change at first, but his mother could be more understanding and help her navigate this new identity.
His relationships with his human friends might become a bit strained at first. He would be spending a lot of time at the academy, away from them. But with his new Shinigami friends, he would develop strong bonds. They would understand his new life and challenges better. For example, he might have a mentor - like relationship with an older student or a friendly rivalry with someone of equal strength.
His relationship with Rukia would be different. Rukia might be more protective of Ichigo in her new form, seeing her as more vulnerable. And with Uryu, he might be more hesitant to interact with Ichigo as a female hollow at first, due to his Quincy beliefs.
His relationship with Kurama might become more complex. Since he's now also a kitsune - like being. They could either become more competitive or find a new way to cooperate. With his friends, some might be in awe of his new form, while others might be a bit scared at first. But Naruto's kind heart would eventually make them all accept him as before.
If Naruto becomes cold - hearted, his relationships with the villagers would change drastically. The villagers, who once saw him as a hero, would now be faced with a cold and unapproachable Naruto. Children who used to look up to him would be scared. His friends from the Akatsuki days, like Nagato, might even see this new Naruto as a threat. Overall, his relationships would go from being warm and friendly to cold and distant, filled with suspicion and unease.
If Naruto becomes a nukenin, his relationship with the village elders would be completely severed. They would see him as a threat, and he would see them as unjust. With his peers, some might side with him, believing in his innocence. Others would follow the village's orders out of loyalty. His bond with the Nine - Tails would also change. The Nine - Tails might offer more support, seeing Naruto as an outcast like itself.
His relationship with Sasuke would be greatly affected. Sasuke, who has his own experiences with the idea of killing, might see Naruto in a new light. They could either become rivals again or Sasuke might try to 'save' Naruto from his new dark path. With Sakura, she would be horrified. She's always seen Naruto as a positive force, and this change would make her question everything. She might even try to use her medical skills to 'cure' Naruto of his new - found killer tendencies.
If Naruto becomes a Saiyan in fanfiction, his relationship with his mentor, like Jiraiya, could be different. Jiraiya would have to guide Naruto in handling these new Saiyan powers. Naruto's friends might be both in awe and a little scared. For example, Sakura might be worried about Naruto losing control of his new powers. And his relationship with the villagers could change too. Some might see him as an even greater protector, while others might fear his new, more alien - like powers.
Aang's relationship with the Air Nomads' spirits could also be affected. As a girl, she might be seen as a new form of the Avatar by the spirits. They could communicate with her in different ways, guiding her on a different path. This could lead to new alliances and ways of using air - bending that were not available to Aang when he was male. Also, her relationship with other female characters in different tribes could become more sisterly, with them sharing secrets and knowledge specific to women.