One plot idea could be that Itachi, in a different timeline where he didn't face all the tragedies so soon, meets Sakura during a mission outside the Leaf Village. They initially start as rivals but gradually come to respect each other's skills. As time passes, they find themselves working together more often and develop a deep friendship that slowly turns into a romantic relationship.
In a fanfiction, Itachi could be resurrected by some experimental jutsu. Sakura, being a medic - nin, is assigned to keep an eye on his health. At first, Itachi is cold and distant, but Sakura's determination to understand him and her kindness start to break through his walls. They then start sharing their past traumas and experiences, which leads to a strong bond between them.
One idea could be a time - travel plot where Sakura is sent back in time and meets Madara. She tries to change his path of destruction. Another could be a scenario where Madara is resurrected in Sakura's time and they have to team up against a new common enemy. Maybe a plot where Madara, in his search for power, discovers Sakura's unique medical and combat abilities and tries to use her for his own gain.
Well, a plot could involve Sakura and Madara being forced to team up against a new, powerful enemy that threatens the entire ninja world. Sakura initially distrusts Madara, but as they fight side by side, she begins to see a different side of him. Maybe there's a plot where Madara is cursed, and Sakura is the only one who can break the curse because of her unique chakra. As she tries to break the curse, they get to know each other better. Or perhaps in a parallel universe, Sakura and Madara are lovers from the start and they have to fight against the forces that want to tear them apart.
A plot where Sakura discovers a hidden connection between Obito and an ancient medical jutsu that was lost. They then embark on a journey together to find more about it, facing various challenges along the way. During this time, they gradually develop a mutual respect and a bond that is different from their normal relationships with others. This journey could also involve encounters with old enemies and new allies, all while exploring the depths of their own capabilities.
One idea could be a time - travel plot. Sakura somehow gets sent back in time and meets Shisui. They form an unlikely alliance as Sakura tries to prevent certain tragedies from happening in the Uchiha clan. This would involve a lot of mystery and action as they work together, with Sakura using her medical ninjutsu knowledge and Shisui his Sharingan abilities.
A plot could revolve around their family planning. Maybe Sakura wants to start a family right away, but Sasuke is hesitant due to his past and the dangerous world they live in. This creates tension between them, and they have to work through their differences and communicate better. They could also face external pressure from the village elders regarding their family plans.
One interesting plot idea could be Sasuke and Sakura going on a dangerous mission together where they have to rely on each other completely. This would strengthen their bond and lead to some deep emotional exchanges.
A story where Shisui survives and he meets Sakura during a mission outside of Konoha. Sakura is initially wary of him because of his Uchiha heritage, but Shisui's gentle nature quickly wins her over. They then team up to complete the mission and in the process, discover they have a lot in common. They start to exchange medical and combat knowledge, which deepens their bond.
One idea could be a time - travel fanfic where Sakura goes back in time and meets a young Shisui Uchiha. She could be on a mission to change certain events in the Uchiha clan's history and ends up forming an unexpected bond with Shisui. They might work together to prevent some of the tragedies that befell the Uchiha.
Another plot could be that Itachi has lost his memories and wakes up in the Highschool DxD world. He slowly regains his skills and memories as he experiences the various events in the school. His relationships with the characters in this new world would be very interesting to explore, especially as he starts to remember his past and how it might relate to the new situation.
One plot idea could be that Sakura, while on a mission, stumbles upon Pein's base by accident. She tries to use her medical skills to heal some of the injured Akatsuki members there as a way to negotiate peace, which surprises Pein. Another could be a time - travel scenario where Sakura goes back in time and meets a younger Pein before he becomes the leader of the Akatsuki, and she tries to change his path. A third idea is that Pein captures Sakura to use her knowledge of medical ninjutsu for his own purposes, but Sakura gradually makes him see the value of life in a different way.