Sasuke and a fox demon with a similar past of loss. Sasuke has his own dark past with the Uchiha clan's massacre. A fox demon who has lost their family or pack could bond with Sasuke over their shared experiences. They might even develop a unique fighting style together, combining Sasuke's Sharingan - enhanced jutsu with the fox demon's special abilities.
Naruto and Inuyasha themselves would be a very intriguing combination. Naruto's positive attitude and never - give - up spirit combined with Inuyasha's rough - around - the - edges but strong - willed personality would create a lot of interesting interactions. They could start off not liking each other but gradually become friends as they face challenges together.
One intriguing combination would be Hermione and Neytiri. Hermione's thirst for knowledge and Neytiri's connection to Pandora's nature could lead to some great interactions. Hermione could learn from Neytiri about the unique flora and fauna of Pandora, and Neytiri could be fascinated by Hermione's magic and her ability to study and understand complex things.
Naruto and Kirby would be really interesting. Kirby could copy Naruto's abilities, like his running speed or his ability to use chakra. And Naruto could be amazed at Kirby's cuteness and his unique way of fighting, like inhaling enemies. They could have a really fun dynamic together.
One of the most intriguing combinations is Harley Quinn and Alice Cullen. Harley's chaotic and unpredictable nature paired with Alice's calm and prescient abilities would create a really interesting dynamic. They could either be at odds or find a strange kind of friendship. Another good combination is Deadshot and Edward Cullen. Deadshot's sharpshooting skills and his more jaded view of the world contrasted with Edward's brooding and his vampiric powers would make for some great scenes.
Aphmau from MyStreet and Freddy Fazbear would be an interesting combination. Aphmau is a strong - willed leader in her world, and seeing her face off against Freddy, the iconic animatronic from FNAF, would be exciting. Another interesting pair could be Aaron from MyStreet and Foxy. Aaron is often protective, and Foxy has that unpredictable nature.
Well, for one, Harrison Wells from Flashpoint and Castiel would be really interesting. Wells is a brilliant scientist, and Castiel is an angel. Wells could be intrigued by Castiel's otherworldly nature and try to study him, while Castiel could use Wells' knowledge to better understand the science - based threats in the Flashpoint universe. Another cool combination would be Felicity Smoak from Flashpoint and Rowena from Supernatural. Felicity is a tech - genius, and Rowena is a powerful witch. They could either be rivals, with Felicity trying to use her tech to counter Rowena's magic, or they could team up and create some really powerful spells or gadgets. And then there's Oliver Queen from Flashpoint and Sam Winchester. Oliver is a skilled archer and fighter, and Sam is a hunter. They could share their combat techniques and knowledge, and together they could take on some really tough opponents in both the Flashpoint and Supernatural worlds.
Definitely Superman and Thor. They both have super strength and are associated with powerful, other - worldly elements. Thor has his hammer and lightning powers, while Superman has his super - strength, heat vision, etc. It would be interesting to see them compete in a friendly strength - based challenge or fight side by side against a really strong foe.
One interesting plot combination could be the use of Crysis' nanosuit technology in the Mass Effect universe. For example, Shepard could get ahold of a prototype nanosuit that gives them enhanced combat abilities, like increased speed and strength, which would be a huge advantage against the Reapers. Another could be the merging of the alien races from both universes. Maybe the Turians and the Ceph could form an uneasy alliance due to a common threat.
One interesting combination could be Cole from Infamous and Jon Snow. Cole has his powers and moral dilemmas, and Jon Snow is all about honor and leadership. Their meeting could lead to some great discussions about power and responsibility. Another would be Fetch from Infamous and Arya Stark. Fetch's edgy nature and Arya's vengeful streak could make for an exciting duo.
Definitely Superman and Luke Skywalker. Luke is all about the Force and becoming a Jedi, while Superman has his own set of powers. They could learn from each other. Luke could teach Superman about the spiritual side of power, and Superman could show Luke how to use physical strength in new ways.