Some in Konoha could become angry with Naruto. They may feel that he has a duty to the village that he is shirking. They might start to spread negative rumors about him, saying that he has forgotten his roots. However, there could also be those in Konoha who understand Naruto's reasons, or at least try to. They might start to look for internal solutions to their problems instead of relying on Naruto.
Konoha might be in shock at first. They have always relied on Naruto to some extent, and his refusal to help is completely unexpected.
Maybe he has some personal grudges against the village. For example, he might have felt betrayed by the village in the past and that made him reluctant to offer help.
Naruto would probably be conflicted. On one hand, he has a deep love for Konoha, his home. But on the other hand, he might have been hurt by the past events that led to his departure. He could initially be hesitant, but eventually be swayed by the thought of seeing his friends again.
Sasuke might be more understanding. Given his own experiences of leaving Konoha, he could respect Naruto's decision. However, he might also secretly plan to keep an eye on Naruto from afar to make sure he is safe.
At first, Naruto is likely to be heartbroken. Konoha has been his home, and he has always longed for acceptance from the villagers. So being abandoned would be a huge blow to him.
He would probably be very angry. Naruto has always been a free - spirited person, and being experimented on against his will would be a huge violation of his rights. He might initially try to resist physically, but as the situation gets more complex, he could start to plot his escape and revenge.
One reason could be that she feels betrayed by Konoha. Maybe she has faced discrimination or unfair treatment there in the past because she's female in a world that might be more used to male ninjas. For example, she could have been passed over for important missions or training opportunities just because of her gender.
Naruto would likely be extremely hurt. He has always considered the Konoha 11 as his friends and comrades. So, at first, he would probably be in denial, trying to figure out what went wrong. He might try to talk to them, to understand their reasons.
Naruto might initially try to reason with those who betrayed him. He would want to understand why they did it. But if they refuse to listen or continue to be hostile, he would start to distance himself from Konoha. He could become a lone wolf, using his skills and power to survive on his own while still trying to figure out how to clear his name and get revenge if necessary. He would also likely feel a sense of betrayal towards the friends he thought he had in Konoha.
The story would also change the perception of Naruto. Instead of being seen as the hero of Konoha, he would be considered a traitor by many. This would create a whole new set of relationships and conflicts. His friends might try to convince him to change his mind, leading to some very emotional and complex storylines. The shinobi world as a whole might start to question the values that Naruto has always represented, like loyalty and perseverance. And if Konoha does fall, it could inspire other villages to reevaluate their own security measures and relationships with their ninjas.
The Hokage, whoever it is at the time, would see Naruto's actions as a major threat. They would likely assemble the ninja forces to defend Konoha. But there would also be a part of them that would wonder what drove Naruto to this. Kakashi, for example, would be conflicted. He has a deep bond with Naruto, but he also has a duty to protect Konoha. So he would try to find a way to end this without harming Naruto too much.