Maybe there could be a new antagonist, a dark shapeshifter who is jealous of Harry's power. This antagonist could be an old wizard who has been in hiding for centuries, waiting for the right time to emerge and take over the wizarding world. He sees Harry as a threat to his plans and tries to eliminate him.
Another possibility is that the Ministry of Magic becomes the main antagonist. They might see Harry's shapeshifting ability as a danger and try to control or eliminate him. They could fear that he might use his power to overthrow the existing magical order, so they send Aurors after him, making them the main source of conflict in the fanfiction.
Perhaps Voldemort himself, even though he doesn't have the natural ability to shapeshift in the original story. In the fanfiction, he could find a way to mimic shapeshifting, or he could use dark magic to control other shapeshifters to go against Harry. This would make for an even more dangerous and complex conflict as Harry has to face his greatest enemy with this new aspect of his powers.
A long - lost relative of Sirius Black could be a shapeshifter. Since the Blacks had many secrets and were involved in a lot of dark magic in their family history, it would be believable for a hidden relative to have this unique ability.
Perhaps a group of rogue ninjas who are threatened by Naruto's shapeshifting ability. They might see him as a threat to their plans and try to eliminate him. They could be led by a mastermind who is well - versed in countering shapeshifting techniques.
Perhaps a long - lost relative of the Potter family who feels they were unjustly excluded from inheriting the manor. This relative could be jealous of Harry's status and the wealth associated with the manor. They might use dark magic to try and claim what they think is rightfully theirs, leading to a battle of magic and loyalty within the Potter family and among Harry's friends.
A new dark wizard or witch could be created specifically for this fanfiction. This character could be interested in using the Huntsman's skills for their own evil purposes. If the Huntsman refuses, they become enemies. This antagonist could have powers related to dark forest magic, something that the Huntsman is familiar with but in a more malevolent form.
Voldemort could still be the main antagonist. Even if Demetri has some sort of connection or change in the fanfiction, Voldemort's overarching evil plans would still be a major threat to both Harry and Demetri, especially if Demetri tries to deviate from the Death Eaters' path.
The minotaur itself could be the main antagonist. It's a powerful and dangerous creature, and if it's been set loose in Hogwarts or is guarding something that Harry needs, it would be a major obstacle for him to overcome.
The main antagonist could be a dark wizard who has made the graveyard his lair. He uses the dark energy from the tombstones and the restless spirits there to power his dark magic. Harry stumbles upon this wizard's activities and has to stop him.
A new dark wizard or witch could be the main antagonist. This character, jealous of Harry's fame and power, creates a situation where Harry is framed for a heinous crime. They then ensure his arrest so that they can take over the role of the 'chosen one' in the eyes of the wizarding public and start spreading their own brand of dark magic.
It could be Malfoy. He might make fun of Harry for wearing a dress and try to use it to humiliate him in front of the whole school, which would then lead to a conflict between them that goes beyond the usual rivalry.