One possible plot could be that the Avengers or other superheroes in the Marvel universe start treating Peter like a baby due to some misunderstanding or magic spell. Maybe they start feeding him baby food and dressing him in baby clothes, which would be really hilarious.
Perhaps Peter gets shrunk to a baby - like size accidentally during an experiment gone wrong. And then his friends and family have to take care of him as if he were a baby. They might struggle with how to handle his superpowers while he's in this state. For example, his spider - sense might go haywire and they have to figure out how to calm him down.
Obviously, Peter Parker himself is the main character. Since he's the one being treated like a baby.
One interesting plot could be that the other Avengers have to take care of baby Peter. They struggle with things like changing diapers and feeding him, all while trying to figure out how to turn him back. It would be really funny to see tough heroes like Thor or Iron Man being clueless about baby care.
Another idea is that Peter is sick and hallucinating. He starts seeing alternate versions of himself from different universes. These versions are trying to tell him something important about his powers or a future threat. But because he's sick, it's hard for him to distinguish between what's real and what's just a fever - induced dream.
One interesting plot could be Peter Parker using his newfound knowledge from his rebirth to prevent some major disasters that originally happened in the Spider - Man storylines. For example, he might be able to stop the death of a certain important character much earlier.
One interesting plot could be Peter Parker adjusting to his blindness while still trying to protect his neighborhood. He might rely more on his other senses like enhanced hearing to detect danger. For example, he could learn to 'hear' the footsteps of approaching villains from a distance. Another plot could involve his friends and family helping him adapt, and in the process, they discover new abilities within him that were previously overlooked due to his focus on his spider - abilities.
One interesting plot could be Peter using his gamer skills to upgrade his Spidey - sense. For example, he might be able to analyze threats more precisely like in a game where he levels up his detection ability.
One interesting plot could be Peter Parker getting lost in a strange dimension and Stephen Strange has to use his magic to find and rescue him. This would involve a lot of cool magical battles and Peter using his spider - skills in an otherworldly setting.
One interesting plot could be that Peter Parker discovers a new form of dance that actually helps him improve his Spider - Man reflexes. He starts secretly training in this dance style in an abandoned warehouse. As he gets better at it, he also uses it to outwit his enemies in a really unique way during battles.
One interesting plot could be that while sleepwalking, Peter Parker accidentally uses his Spider - Man abilities. He might swing between buildings unconsciously, causing chaos in the city. People are both amazed and worried as they see Spider - Man acting so strangely.
One interesting plot could be Peter adjusting to the social differences. As a girl, she might face different expectations in school or among friends. For example, she may notice different treatment from teachers or classmates. Another plot could involve her superhero activities. Maybe she has to adapt her fighting style to fit her new physical form, or deal with villains who react differently to a female Spider - Person.