One interesting plot could be Peter Parker adjusting to his blindness while still trying to protect his neighborhood. He might rely more on his other senses like enhanced hearing to detect danger. For example, he could learn to 'hear' the footsteps of approaching villains from a distance. Another plot could involve his friends and family helping him adapt, and in the process, they discover new abilities within him that were previously overlooked due to his focus on his spider - abilities.
Perhaps Peter starts a support group for other disabled individuals in the city while dealing with his own blindness. Through this, he gains a new perspective on life and how to use his powers for a different kind of good. His experiences in the support group could then inspire him to create new gadgets or techniques that are more accessible to him and others with disabilities when it comes to fighting crime.
One interesting plot could be Peter using his gamer skills to upgrade his Spidey - sense. For example, he might be able to analyze threats more precisely like in a game where he levels up his detection ability.
One interesting plot could be that while sleepwalking, Peter Parker accidentally uses his Spider - Man abilities. He might swing between buildings unconsciously, causing chaos in the city. People are both amazed and worried as they see Spider - Man acting so strangely.
One interesting plot could be Peter adjusting to the social differences. As a girl, she might face different expectations in school or among friends. For example, she may notice different treatment from teachers or classmates. Another plot could involve her superhero activities. Maybe she has to adapt her fighting style to fit her new physical form, or deal with villains who react differently to a female Spider - Person.
In some, Peter uses Italian to charm a love interest. For example, he might meet an Italian girl during his travels and his ability to speak her language makes him more attractive.
Another plot might involve Peter and Liz going on a school trip together, and during the trip, they face some sort of danger that only Spider - Man can handle. Peter has to balance his feelings for Liz with his responsibility as Spider - Man, and Liz starts to see Peter in a whole new light.
One possible plot could be that Peter Parker discovers ballet as a form of unique training for his superhero agility. He might start taking ballet classes secretly, and then his friends in the superhero world find out and are initially confused but later impressed by how it enhances his combat skills.
One plot could be Peter using his scientific skills, learned from school and his own natural talent, to contribute to a major project at Stark Industries. Maybe he helps in developing a new type of web - shooting technology that is more efficient and has additional features like being able to detect different substances. Another plot could involve Peter getting involved in a mystery within the company, perhaps something to do with stolen tech blueprints. He would use his Spider - Sense and detective skills to solve the mystery and save Stark Industries from a potential disaster. Also, a plot could be about Peter making friends with other employees at Stark Industries and learning from their different areas of expertise, which in turn helps him become a better superhero.
One interesting plot could be that the other Avengers have to take care of baby Peter. They struggle with things like changing diapers and feeding him, all while trying to figure out how to turn him back. It would be really funny to see tough heroes like Thor or Iron Man being clueless about baby care.
One possible plot could be that the Black Cat licks Peter Parker as a form of affection, and this becomes a unique way for her to show her feelings in a world where their relationship is full of secrecy and danger. Maybe it's a sign of trust she's building with him.
One possible plot could be that the Avengers or other superheroes in the Marvel universe start treating Peter like a baby due to some misunderstanding or magic spell. Maybe they start feeding him baby food and dressing him in baby clothes, which would be really hilarious.