Definitely Sans and Spider - Man. Sans is known for his laid - back yet intelligent nature. He would be curious about Spider - Man's powers and his sense of justice. Spider - Man, on the other hand, would be intrigued by Sans' magic and his non -chalant attitude towards danger. Their interactions could range from friendly banter to serious discussions about how to protect their respective worlds.
Papyrus would also be a great character to interact with Spider - Man. Papyrus is full of enthusiasm and always eager to prove himself. He could see Spider - Man as a hero he wants to emulate. Spider - Man could help Papyrus understand the concept of true heroism, which is not just about getting recognition but also about doing the right thing for the sake of others. They could train together, with Spider - Man teaching Papyrus some new combat moves using his webs.
Frisk could interact with Spider - Man as well. Frisk is the main character in Undertale who has a strong sense of determination. They could bond over their shared will to persevere in difficult situations. Spider - Man could be a mentor - like figure to Frisk, showing them different ways to use their determination in more practical ways outside of the Underground. And Frisk could introduce Spider - Man to the unique culture and customs of the Underground.
Sub - Zero could also interact with Spider - Man. Sub - Zero's ice powers would be a new and dangerous threat for Spider - Man. He'd need to figure out how to avoid being frozen while using his webs to trip up Sub - Zero. And on the other hand, Sub - Zero might be intrigued by Spider - Man's unique abilities and want to test his own skills against him. Another likely pair could be Spider - Man and Raiden. Raiden, as a powerful thunder god, could either be an ally or an opponent. If he's an ally, he could help Spider - Man fight against some powerful evil force that has invaded both their worlds. If an opponent, Spider - Man would have to find a way to avoid Raiden's lightning attacks.
I think Quinn and Black Widow would be an interesting pair. Quinn is used to being in a position of power and popularity in the Glee club, and Black Widow is a strong female character in the Avengers. They could have some really cool exchanges about strength and femininity.
I think Sakura from Naruto and Stella from Winx could interact a lot. Sakura is a strong - willed and intelligent kunoichi, and Stella is a confident and powerful fairy. They could have some really interesting conversations about their respective worlds, like comparing the medical ninjutsu in Naruto's world to the healing magic in the Winx world. And they might also get into some friendly rivalries while training together.
Definitely Ruby Rose and Master Chief. Ruby is the main character in RWBY, full of energy and determination. Master Chief is a well - known and iconic figure in Halo. Their different personalities and combat styles would create an interesting dynamic. Ruby's quick - thinking and agility could pair well with Master Chief's stoic and strategic approach in battles.
Bloom and Iron Man could be likely to interact. Bloom is a powerful fairy with strong leadership qualities, and Iron Man is a genius inventor and leader in the MCU. They could both exchange ideas about leadership and power, and maybe Bloom could teach Tony a thing or two about magic. Another pair could be Stella and Thor. Stella loves fashion and luxury, and Thor is from a royal background in Asgard, so they could bond over their love for grandeur.
It could be Zane from Ninjago and Trixie from Slugterra. Zane is very logical and has a lot of knowledge about technology and combat strategies. Trixie is smart and resourceful in the world of Slugterra. They might cross paths while investigating some strange occurrences that seem to be related to the crossover. Their initial meeting would probably involve a lot of questions and mutual curiosity as they try to figure out where the other is from and what they are doing in this new, combined situation.
I think Tony Stark and Damon Salvatore would be very likely to interact. Tony with his high - tech gadgets and Damon with his vampire charm and quick - witted nature. They could have some really interesting banter, like trading sarcastic remarks while trying to solve a common problem.
Obviously, Harry Potter and Riddick would interact. Harry, being the main hero in his world, would be curious about Riddick's strange abilities and his rough - and - tumble way of life. Riddick, on the other hand, would likely be suspicious of Harry at first but then come to respect his magical powers.
Mercy from Overwatch and the Medic from TF2 could be the first to interact. Given their roles as healers, they would likely be interested in each other's medical techniques. They might start by comparing notes on how to heal their comrades more effectively, and this could lead to a deeper understanding and cooperation between the two groups.
Yoda and Alfred could also have an interaction. Yoda is a wise Jedi master, and Alfred is Batman's wise and loyal butler. They could exchange wisdom and perhaps Yoda could give Alfred some insights about the Force that Alfred could then use to help Batman in some way.