A lot of people would say that 'Alex Cross' series in general represents his best work. Books like 'Cross' are full of action, complex psychological profiling, and great character arcs for Alex Cross. The series has been popular for a long time, which indicates its high quality.
I think 'When the Wind Blows' is often regarded as a top - notch Patterson novel. It has a unique and somewhat fantastical element to it while still maintaining the mystery and suspense that Patterson is known for. The story about the children with special abilities is both engaging and thought - provoking.