The werewolf's past and family situation could also pose challenges. Maybe they come from a family that has a bad reputation in the werewolf community or among wizards. This could make it difficult for Harry and the werewolf to fully trust each other at first. And as they grow closer, the werewolf might worry about dragging Harry into their family's problems or being rejected because of it.
Their different backgrounds would be a big challenge. Harry grew up in the Muggle world and has a very different set of values compared to Draco, who was raised in a pure - blood supremacist family. Their friends might also oppose their friendship. Harry's Gryffindor friends might not trust Draco easily, and Draco's Slytherin friends could see his friendship with Harry as a betrayal.
Hermione would also face the challenge of secrecy. If the wrong people found out, it could put her in danger. And she might have to constantly lie to her friends and family, which would be really hard for someone as honest as her. In some fanfictions, this internal struggle is really well - explored.
One challenge could be dealing with society's lack of understanding. Some people might make unfounded assumptions about their relationship, which can be frustrating. For example, they might be wrongly assumed to be in a romantic relationship when they are just good friends.
She might face discrimination. In the ninja world where she comes from, werewolves could be seen as monsters. So she'd have to deal with people being afraid of her or trying to hunt her down.
One major challenge is Harry's initial distrust. Harry has known Snape as a mean - spirited teacher, so it's hard for him to accept Snape as a guardian right away. Also, Snape has to protect Harry from the threats of the wizarding world, such as Voldemort's followers. He has to constantly be on guard and anticipate any potential attacks. Another challenge is dealing with Harry's friends. They might be suspicious of Snape too, which could create problems when Snape is trying to keep Harry safe and make decisions for him.
Another challenge would be his changed appearance. His fangs and pale complexion could make it difficult for him to blend in at Hogwarts. He might be ostracized by some students and even some teachers. His vampiric abilities, while useful in some ways, could also be a hindrance as he tries to maintain his normal wizard life. For instance, his sensitivity to sunlight could limit his outdoor activities during the day.
In a fanfic, Harry as a girl would face the challenge of re - defining her identity. She has been known as a male hero, and now she has to create a new image for herself. This could be difficult in the wizarding community where reputations are important. She would also have to adapt to the physical differences, like having a different body structure for dueling or flying on a broomstick, which could take time to get used to.
One challenge would be Harry's strong will. He has his own beliefs and values that are opposed to Bellatrix's dark ideology. Another challenge could be hiding Harry from Voldemort. Voldemort might not approve of Bellatrix raising Harry in her own way. Also, Bellatrix herself has a reputation to uphold among the Death Eaters, and raising Harry could be seen as a risky and strange move.
Well, it could be at Hogwarts. There could be a situation where the werewolf is a new student or perhaps someone who has been hiding their identity. Harry, being the curious and kind - hearted person he is, might notice something odd about this younger character and start to befriend them, not knowing at first that they're a werewolf.
He could face bullying. There might be some students who look down on him because of his orphan status. They could tease him or exclude him from group activities, making it difficult for him to make friends and feel comfortable at Hogwarts.