She might face discrimination. In the ninja world where she comes from, werewolves could be seen as monsters. So she'd have to deal with people being afraid of her or trying to hunt her down.
Sakura Haruno might struggle with her identity. She has been a ninja for a long time, and now being a werewolf changes everything. She has to figure out how to be both a werewolf and a ninja, and how to integrate her new identity into her existing relationships. For example, she may worry about how Naruto and Sasuke will react when they find out she's a werewolf.
Controlling her werewolf form could be a huge challenge. Maybe during a full moon, she has a hard time suppressing her instincts and she could accidentally harm her friends or loved ones. Also, she would need to find a way to balance her normal ninja abilities with her werewolf powers.
She might face the challenge of being bullied by other inmates. Since she's a ninja, some might see her as a threat or just pick on her because she's different. Also, the lack of proper medical supplies could be an issue for her if she wants to continue using her medical skills, either to help herself or others.
Their different upbringings might also pose a problem. Sakura grew up in a more normal ninja family environment in Konoha, while Gaara had a very traumatic and isolated childhood in Suna. This could lead to differences in how they view relationships and family. For example, Gaara might be more hesitant to open up fully because of his past experiences.
Sakura might face the challenge of public perception. Since her power is so dangerous, people around her may be afraid of her. This could lead to her being isolated or distrusted. Also, in a battle, if she uses her power too much, it could drain her energy quickly, leaving her vulnerable to counter - attacks.
Hermione would also face the challenge of secrecy. If the wrong people found out, it could put her in danger. And she might have to constantly lie to her friends and family, which would be really hard for someone as honest as her. In some fanfictions, this internal struggle is really well - explored.
They might face social stigma. In the ninja world, relationships are often complex and there could be those who don't approve of their union. Also, Sakura's career as a ninja could be affected. She might have to take a break from her duties, which could be a difficult decision for her as she is a dedicated shinobi.
There are several challenges. Firstly, Sasuke's past actions might have made some people in the ninja world resent him, and they could take it out on his family. Secondly, Sakura is still a ninja herself, and she might struggle to balance her pregnancy and her ninja duties. And lastly, they need to prepare for the arrival of the baby, which includes things like finding a safe place to live and getting the necessary supplies in a world that can be quite harsh.
One challenge is to make their relationship believable. Madara is from a different era and has very different values compared to Sakura. Another is to balance their power levels. Madara is extremely powerful, and Sakura, while strong, is not on the same level. So, it's hard to create scenarios where she can hold her own against him without making it seem unrealistic. Also, staying true to their original characters can be difficult when creating new situations for them in the fanfiction.
One challenge could be Sasuke's uncooperative attitude. Given his independent and often brooding nature, he might not be the easiest patient. He may resist certain treatments or not follow Sakura's medical advice properly. Another challenge could be dealing with his past traumas. If his injuries are related to some deep - seated emotional issues from his past battles or family history, Sakura would have to be careful in how she approaches his treatment both physically and mentally.
In this fanfiction, perhaps there is a magical accident that causes Harry Potter to have visions of Sakura Haruno. Driven by his curiosity, he uses magic to find a way to her world. Once there, he discovers that Sakura is facing some sort of danger in her own village. Harry decides to use his magic to help her, and in the process, they develop a deep bond. Sakura, in turn, teaches Harry some of the ninja ways, and they work together to overcome the challenges in both their worlds, creating a unique cross - universe adventure.
She might be tied up because she's been captured by an enemy. Enemies could see her as a valuable hostage, either to get information from her or to use her to bargain with her team.