One possible plotline could be Fem Itachi becoming Naruto's mentor. Since Itachi is highly skilled, she could pass on unique jutsu and strategic knowledge to Naruto. Another plotline might involve a romantic relationship between them, which would be a huge departure from the original story and would create a lot of drama as they navigate their feelings while dealing with the ninja world's challenges. Or perhaps Fem Itachi joins Naruto in his quest to bring peace to the ninja world, using her own methods and abilities to complement Naruto's.
Some plotlines could revolve around Fem Itachi's past. Maybe she has a tragic backstory that Naruto helps her overcome. For example, she was once betrayed by her own clan, and Naruto's kindness and belief in her make her see a different way forward. Or she could be on a mission to find a cure for a curse that affects her, and Naruto, with his never - give - up attitude, joins her on this journey. This could involve them traveling to different hidden villages, encountering various enemies and allies along the way.
Fem Itachi changes the Naruto universe by adding a different dynamic to the power structure. Her female presence brings a new perspective. For instance, she might approach battles and negotiations differently than male characters. She could also influence the relationships between characters. If she becomes friends with Naruto early on, she might change how he views certain clans or ninja techniques.
One possible plotline could be the challenges they face in a world that might not be accepting of their relationship. With Itachi being pregnant, they have to deal with secrecy and the potential danger that could come to their unborn child from various forces in the Naruto universe.
Another plotline might involve Itachi protecting Naruto from the Akatsuki. Since Itachi has his own motives within the Akatsuki, he could use his position to keep Naruto safe from the other members who might be after the Nine - Tails. It would add a lot of tension and drama to the story, especially when Itachi has to balance his loyalty to the Akatsuki and his new - found role as Naruto's protector.
One possible plotline could be Itachi teaching Naruto advanced jutsu techniques. For example, Itachi might show Naruto how to use his chakra more efficiently in combat, which could give Naruto an edge against stronger opponents. Another plotline could involve Itachi sharing some of the secrets of the Uchiha clan with Naruto, like the true nature of the Sharingan. This could lead to Naruto developing new strategies that combine his own abilities with what he's learned from Itachi.
A plotline might involve the two of them in a world where gender roles are more fluid. Effeminate Naruto and fem Itachi could be part of a mission together, and during the process, they discover new aspects of each other's personalities. For example, Naruto's kind - heartedness and Itachi's hidden soft side. Their relationship could develop from mutual respect to something deeper as they face various challenges. And perhaps they have to deal with the reactions of their friends and the ninja community to their relationship, which adds more drama to the story.
One possible plotline is that Fem Naruto and Itachi are assigned to protect a valuable village asset. Along the way, they face numerous enemies and have to work together to overcome them. As they fight side by side, they start to respect each other's abilities more.
Naruto would probably be very confused at first. He's always seen the Akatsuki as the enemy, so being taken there by Fem Itachi would be quite a shock. He might be on guard and constantly looking for a way to escape.
Well, perhaps in this fanfiction, Fem Orochimaru takes Naruto because she believes he has the potential to unlock a powerful transformation that she has been researching. She kidnaps him in a rather unorthodox way but then realizes that Naruto is not going to be compliant without some sort of deal. So they strike a bargain. As they work together, Naruto starts to understand Fem Orochimaru's past and her reasons for her actions. And Fem Orochimaru starts to have a soft spot for Naruto, which is completely unexpected for her.
One possible plot twist could be that Fem Itachi has a hidden agenda in taking Naruto to the Akatsuki. Maybe she's actually trying to protect Naruto from a greater threat by pretending to bring him to the Akatsuki. Another could be that Naruto discovers a long - lost connection between his family and the Akatsuki through this journey, which changes his perspective on the whole situation.
One interesting plotline could be Hinata becoming a powerful ninja in her own right and protecting Naruto instead of the other way around. For example, she could master a new and unique jutsu that saves Naruto from a powerful enemy.