It could be some rogue ninjas who were against the peace treaties after the war. They might form a group and try to disrupt the newly - established peace in the ninja world.
A group of corrupt politicians within the village itself could be the main antagonists. They might be secretly plotting to undermine Naruto's authority as the 5th Hokage in order to gain more power for themselves. They could be making deals with other villages or ninja groups that are not in the best interest of Konoha, and Naruto has to expose and stop their schemes.
It could be some of the old enemies who were thought to be defeated but managed to come back. For example, Orochimaru's former followers who still hold a grudge against Naruto and Konoha. They might see Naruto's retirement as an opportunity to strike.
Perhaps a secret organization that had been hidden for centuries and didn't want the new order that Konoha represented. They could have dark magic or forbidden jutsu at their disposal and use it to try and stop the First Hokage from achieving his goals. This would force the First Hokage to not only rely on his physical strength and known ninja techniques but also to find ways to counter the unknown and mysterious powers of this secret organization.
Perhaps a powerful and corrupt merchant group could be the antagonists. They are secretly trying to take over the village's economy and resources. They use bribes and blackmail to get their way. The Sixth Hokage discovers their plot and has to stop them without causing too much chaos in the village's economic system. They may also have some ninja mercenaries working for them.
There could be a new group of villains who emerged from the shadows. They might have been observing the war and learned from the mistakes of previous antagonists. They could be more powerful and cunning, perhaps using new forms of jutsu or technology that were developed during the war. Maybe they are after some ancient artifacts or secrets that were unearthed during the Fourth Great Ninja War.
Some former Death Eaters who escaped justice could be the main antagonists. They might be plotting to bring back Voldemort's ideology in a more covert way. Another possibility could be new dark wizards who emerge, seeing the post - war chaos as an opportunity to gain power.
In such a fanfiction, Naruto might focus on rebuilding the village. He could start new training programs for the young ninjas to ensure the village's future protection.
It could be some remaining monsters that survived the giant war and are now seeking revenge. They might target Nico specifically because of his role in the war. Another possibility is some rogue demigods who didn't like the outcome of the war and blame Nico for it.
Some of the pure - blood supremacist families who still hold grudges against Harry could be antagonists. They might not approve of Daphne getting involved with Harry, seeing him as a threat to their traditional values. For example, some of Daphne's extended family members who are still stuck in the old ways could try to break them up.
Another option for antagonists could be a new organization that rises in the power vacuum left after the war. They might have different ideologies from Naruino and his village. For example, they could believe in total domination rather than the peace and co - existence that Naruino stands for. They would see Naruino as a threat to their plans and try to eliminate him.