The friends could play important roles in the baby's life. They could be like extended family. For example, their friends could introduce the baby to different hobbies and interests as the baby grows up. Carly could expose the baby to the world of web shows, Gibby to his unique form of physical comedy, and Spencer to the arts. Their friends would be there to shape the baby's world in a positive way.
Sam would probably be very protective. He has always been there for Dean, and now with a new addition to the family in the form of a baby, he would see it as his responsibility to keep the baby safe. He might also be a bit of a mentor, teaching the baby about the world of hunting and how to handle different supernatural creatures.
It might be a story of how Sam and Freddie's relationship changes with the arrival of the baby. At first, they could be stressed and argue a lot more. But as they grow into their roles as parents, they become closer and more in love. They learn to communicate better through the process of taking care of their child and their relationship evolves into a more mature and stable one.
Their friends would probably be really excited at first. Raven might be a bit reserved but still happy for them. Cyborg would likely be the most enthusiastic, already thinking about building cool toys for the baby.
Sakura would probably be a bit surprised at first, but then she'd be happy for Naruto. She might offer to help with the baby's medical needs. Kakashi would be his usual calm self, giving Naruto some sage advice on fatherhood. As for Konan's friends from Amegakure, they might be a bit more hesitant, but once they see how happy Konan is, they would come around and support the new family.
Well, some friends might be a bit worried at first. If Serena and Darien are new to parenting, their friends could be concerned that they won't be able to handle it. But then as they see Serena and Darien adapt, the friends would become more supportive and be there for them.
Their friends would be really excited. Chad would probably be happy and offer to help with any heavy lifting or physical tasks around the house for when the baby arrives. Uryu might be a bit more reserved but still show his support in his own way, like making some special baby clothes. Rukia would be thrilled and would be constantly visiting, giving Orihime advice on motherhood.
Kim might be shocked at first. She's used to Ron being her sidekick and Shego being an enemy. But she could come around and be a sort of godmother figure, helping out when needed. Rufus would probably be excited. He'd be like a little furry uncle to the baby, always there to play and keep the baby entertained.
The friends would probably be a great support system. May and Max could bring gifts for the baby, like cute Pokémon toys. Dawn might offer to babysit so Ash and Misty could have some time for themselves. All of their friends would be there to celebrate the new addition to the family and would help out in different ways as the baby grows up.
Pikachu would probably be very protective of the baby. Since he's Ash's closest Pokémon partner, he'd be like a little guardian. Brock would likely offer his help and advice on taking care of the baby, as he has some knowledge about it. Misty might be a bit shocked at first but would eventually warm up and be like an aunt to the baby.
Tails would probably be really excited. He'd be the helpful uncle, always ready to use his mechanical skills to make cool toys for the baby. Knuckles might be a bit more gruff at first, but deep down he'd be protective of the little one. Amy would be over the moon and would constantly offer to babysit so she could play with the baby.